دورية أكاديمية
Deletion of the ORF9p acidic cluster impairs the nuclear egress of Varicella-zoster virus capsids.
| العنوان: | Deletion of the ORF9p acidic cluster impairs the nuclear egress of Varicella-zoster virus capsids. |
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| المؤلفون: | Riva, Laura, Thiry, Marc, Lebrun, Marielle, L'Homme, Laurent, Piette, Jacques, Sadzot-Delvaux, Catherine |
| المساهمون: | GIGA-I3 - Giga-Infection, Immunity and Inflammation - ULiège |
| المصدر: | Journal of Virology (2014) |
| بيانات النشر: | American Society for Microbiology |
| سنة النشر: | 2014 |
| المجموعة: | University of Liège: ORBi (Open Repository and Bibliography) |
| مصطلحات موضوعية: | Varicella zoster virus, nuclear egress, Life sciences, Biochemistry, biophysics & molecular biology, Sciences du vivant, Biochimie, biophysique & biologie moléculaire |
| الوصف: | peer reviewed ; The protein encoded by the ORF9 is essential for Varicella-zoster virus (VZV) replication. Previous studies documented its presence in the trans-Golgi network and its involvement in secondary envelopment. In this work, we deleted the ORF9p acidic cluster, destroying its interaction with ORF47p and resulting in a nuclear accumulation of both proteins. This phenotype results to an accumulation of primary enveloped capsids in the perinuclear space, reflecting a capsid de-envelopment defect. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0022-538X 1098-5514 |
| العلاقة: | urn:issn:0022-538X; urn:issn:1098-5514; https://orbi.uliege.be/handle/2268/183229Test; info:hdl:2268/183229; https://orbi.uliege.be/bitstream/2268/183229/1/J.%20Virol.-2015-Riva-2436-41.pdfTest; scopus-id:2-s2.0-84921689781; info:pmid:25473054 |
| DOI: | 10.1128/JVI.03215-14 |
| الإتاحة: | https://doi.org/10.1128/JVI.03215-14Test https://orbi.uliege.be/handle/2268/183229Test https://orbi.uliege.be/bitstream/2268/183229/1/J.%20Virol.-2015-Riva-2436-41.pdfTest |
| حقوق: | open access ; http://purl.org/coar/access_right/c_abf2Test ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.17AEF45 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 0022538X 10985514 |
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| DOI: | 10.1128/JVI.03215-14 |