التفاصيل البيبلوغرافية
| العنوان: |
Gene-age interactions in blood pressure regulation: A large-scale investigation with the CHARGE, global BPgen, and ICBP consortia |
| المؤلفون: |
Simino, J. (Jeannette), Shi, G. (Gang), Bis, J.C. (Joshua), Chasman, D.I. (Daniel), Ehret, G.B. (Georg), Gu, X. (Xiangjun), Guo, X. (Xiuqing), Hwang, S.J., Sijbrands, E.J.G. (Eric), Smith, A.V. (Davey), Verwoert, G.C. (Germaine), Bragg-Gresham, J.L. (Jennifer L.), Cadby, G. (Gemma), Chen, P. (Ping), Cheng, C-Y. (Ching-Yu), Corre, T. (Tanguy), Boer, R.A. (Rudolf) de, Goel, A. (Anuj), Johnson, T. (Toby), Khor, C.C., Lluís-Ganella, C. (Carla), Luan, J., Lyytikäinen, L.-P. (Leo-Pekka), Nolte, I.M. (Ilja), Sim, X. (Xueling), Sõber, S. (Siim), Most, P.J. (Peter) van der, Verweij, N. (Niek), Zhao, J.H. (Jing Hua), Amin, N. (Najaf), Boerwinkle, E.A. (Eric), Bouchard, C. (Claude), Dehghan, A. (Abbas), Eiriksdottir, G. (Gudny), Elosua, R. (Roberto), Franco, O.H. (Oscar), Gieger, C. (Christian), Harris, T.B. (Tamara), Hercberg, S. (Serge), Hofman, A. (Albert), James, A.L. (Alan), Johnson, A.D. (Andrew), Kähönen, M. (Mika), Khaw, K-T. (Kay-Tee), Kutalik, Z. (Zoltán), Larson, M.G. (Martin), Launer, L.J. (Lenore), Li, G. (Guo), Liu, J. (Jianjun), Liu, K. (Kiang), Morrison, A.C. (Alanna), Navis, G. (Gerjan), Ong, R.T.H. (Rick Twee-Hee), Papanicolau, G.J. (George), Penninx, B.W.J.H. (Brenda), Psaty, B.M. (Bruce), Raffel, L.J. (Leslie), Raitakari, O. (Olli), Rice, K. (Kenneth), Rivadeneira Ramirez, F. (Fernando), Rose, L.M. (Lynda), Sanna, S. (Serena), Scott, R.A. (Robert), Siscovick, D.S. (David), Stolk, R.P. (Ronald), Uitterlinden, A.G. (André), Vaidya, D. (Dhananjay), Klauw, M.M. (Melanie) van der, Vasan, R.S. (Ramachandran Srini), Vithana, E.N. (Eranga), Völker, U. (Uwe), Völzke, H. (Henry), Watkins, H. (Hugh), Young, T.L. (Terri), Aung, T. (Tin), Bochud, M. (Murielle), Farrall, M. (Martin), Hartman, C.A. (Catharina), Laan, M. (Maris), Lakatta, E. (Edward), Lehtimäki, T. (Terho), Loos, R.J.F. (Ruth), Lucas, G. (Gavin), Meneton, P. (Pierre), Palmer, C. (Cameron), Rettig, R. (Rainer), Snieder, H. (Harold), Tai, E.S. (Shyong), Teo, Y.-Y. (Yik-Ying), Harst, P. (Pim) van der, Wareham, N.J. (Nick), Wijmenga, C. (Cisca), Wong, T.Y. (Tien Yin), Fornage, M. (Myriam), Gudnason, V. (Vilmundur), Levy, D. (Daniel), Palmas, W. (Walter), Ridker, P.M. (Paul), Rotter, J.I. (Jerome), Duijn, C.M. (Cornelia) van, Witteman, J.C.M. (Jacqueline), Chakravarti, A. (Aravinda), Rao, D.C. (Dabeeru C.) |
| المصدر: |
American Journal of Human Genetics vol. 95 no. 1, pp. 24-38 |
| سنة النشر: |
2014 |
| المجموعة: |
RePub - Publications from Erasmus University, Rotterdam |
| الوصف: |
Although age-dependent effects on blood pressure (BP) have been reported, they have not been systematically investigated in large-scale genome-wide association studies (GWASs). We leveraged the infrastructure of three well-established consortia (CHARGE, GBPgen, and ICBP) and a nonstandard approach (age stratification and metaregression) to conduct a genome-wide search of common variants with age-dependent effects on systolic (SBP), diastolic (DBP), mean arterial (MAP), and pulse (PP) pressure. In a two-staged design using 99,241 individuals of European ancestry, we identified 20 genome-wide significant (p≤ 5 10) loci by using joint tests of the SNP main effect and SNP-age interaction. Nine of the significant loci demonstrated nominal evidence of age-dependent effects on BP by tests of the interactions alone. Index SNPs in the EHBP1L1 (DBP and MAP), CASZ1 (SBP and MAP), and GOSR2 (PP) loci exhibited the largest age interactions, with opposite directions of effect in the young versus the old. The changes in the genetic effects over time were small but nonnegligible (up to 1.58 mm Hg |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
http://repub.eur.nl/pub/57058Test; urn:hdl:1765/57058 |
| DOI: |
10.1016/j.ajhg.2014.05.010 |
| الإتاحة: |
https://doi.org/10.1016/j.ajhg.2014.05.010Test
http://repub.eur.nl/pub/57058Test |
| حقوق: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.17768625 |
| قاعدة البيانات: |
BASE |
