التفاصيل البيبلوغرافية
| العنوان: |
Table_1_SARS-CoV-2 infection predicts larger infarct volume in patients with acute ischemic stroke.DOCX |
| المؤلفون: |
Manuela De Michele (6506996), Svetlana Lorenzano (7551182), Paola Piscopo (9442844), Roberto Rivabene (14368299), Alessio Crestini (5933606), Antonio Chistolini (14368302), Lucia Stefanini (11994902), Fabio M. Pulcinelli (14368305), Irene Berto (13260301), Roberta Campagna (14368308), Paolo Amisano (14368311), Marta Iacobucci (13260298), Carlo Cirelli (9744462), Anne Falcou (9744465), Ettore Nicolini (14368314), Oscar G. Schiavo (13260307), Danilo Toni (5242841) |
| سنة النشر: |
2023 |
| مصطلحات موضوعية: |
Cardiology, Cardiology (incl. Cardiovascular Diseases), Cardiorespiratory Medicine and Haematology not elsewhere classified, stroke, SARS-CoV-2, COVID-19, coagulation, thrombosis, platelet activation, endothelium activation |
| الوصف: |
Background and purpose Acute ischemic stroke (AIS) is a fearful complication of Coronavirus Disease-2019 (COVID-19). Aims of this study were to compare clinical/radiological characteristics, endothelial and coagulation dysfunction between acute ischemic stroke (AIS) patients with and without COVID-19 and to investigate if and how the SARS-CoV-2 spike protein (SP) was implicated in triggering platelet activation. Methods We enrolled AIS patients with COVID-19 within 12 h from onset and compared them with an age- and sex-matched cohort of AIS controls without COVID-19. Neuroimaging studies were performed within 24 h. Blood samples were collected in a subset of 10 patients. Results Of 39 AIS patients, 22 had COVID-19 and 17 did not. Admission levels of Factor VIII and von Willebrand factor antigen were significantly higher in COVID-19 patients and positively correlated with the infarct volume. In multivariate linear regression analyses, COVID-19 was an independent predictor of infarct volume (B 20.318, Beta 0.576, 95%CI 6.077–34.559; p = 0.011). SP was found in serum of 2 of the 10 examined COVID-19 patients. Platelets from healthy donors showed a similar degree of procoagulant activation induced by COVID-19 and non-COVID-19 patients' sera. The anti-SP and anti-FcγRIIA blocking antibodies had no effect in modulating platelet activity in both groups. Conclusions SARS-CoV-2 infection seems to play a major role in endothelium activation and infarct volume extension during AIS. |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/dataset/Table_1_SARS-CoV-2_infection_predicts_larger_infarct_volume_in_patients_with_acute_ischemic_stroke_DOCX/21854262Test |
| DOI: |
10.3389/fcvm.2022.1097229.s004 |
| الإتاحة: |
https://doi.org/10.3389/fcvm.2022.1097229.s004Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.1772A13F |
| قاعدة البيانات: |
BASE |
