دورية أكاديمية
IgG abnormalities in HIV-positive Malawian women initiating antiretroviral therapy during pregnancy persist after 24 months of treatment
| العنوان: | IgG abnormalities in HIV-positive Malawian women initiating antiretroviral therapy during pregnancy persist after 24 months of treatment |
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| المؤلفون: | Baroncelli S., Maria Galluzzo C., Liotta G., Orlando S., Ciccacci F., Andreotti M., Mpwhere R., Luhanga R., Sagno J. B., Amici R., Marazzi M. C., Giuliano M. |
| المساهمون: | Baroncelli, S, Maria Galluzzo, C, Liotta, G, Orlando, S, Ciccacci, F, Andreotti, M, Mpwhere, R, Luhanga, R, Sagno, Jb, Amici, R, Marazzi, Mc, Giuliano, M |
| بيانات النشر: | ELSEVIER SCI LTD |
| سنة النشر: | 2019 |
| المجموعة: | Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca |
| مصطلحات موضوعية: | Africa, HIV, Hypergammaglobulinemia, IgG subclasse, Pregnancy, Adult, Anti-Retroviral Agent, CD4 Lymphocyte Count, Female, HIV Infection, HIV Seropositivity, Human, Immunoglobulin G, Malawi, Postpartum Period, Young Adult, Settore MED/42 - IGIENE GENERALE E APPLICATA |
| الوصف: | Objectives: Hypergammaglobulinemia and anomalies in the IgG subclass distribution are common in HIV-infected individuals and persist even after many years of antiretroviral therapy (ART). The aim of this study was to investigate the IgG profile and dynamics in pregnant HIV-infected Malawian women in the Option B era.Methods: Thirty-seven treatment-naive women received ART from the third trimester of pregnancy to 6 months post delivery (end of the breastfeeding period). ART continuation (group C) or interruption (group I) was then decided on the basis of the CD4+ cell count at enrolment (>350 or <= 350/mu l). Total IgG and IgG subclasses were determined in maternal serum using a nephelometric assay at baseline and at 6 and 24 months postpartum.Results: At enrolment, 36/37 women had IgG levels >15 g/l and there was a predominance of the IgG1 isotype (more than 90%) in parallel with underrepresentation of IgG2 (5.0%). After 6 months of ART, both groups showed a significant median decrease in total IgG (-3.1 g/l in group I, -3.5 g/l in group C) and in IgG1 (-4.0 g/l and -3.6 g/l, respectively), but only a modest recovery in IgG2 levels (+0.16 in group I, +0.14 g/l in group C). At month 24, hypergammaglobulinemia was still present in 73.7% of women in group C, although a significant reduction was observed in total IgG level and in IgG1 and IgG3 subclasses (p < 0.0001 in all cases). IgG2 levels did not show any significant change. In group I at 24 months, total IgG and IgG subclasses had returned to levels comparable to those at baseline.Conclusions: The beneficial effects of 24 months of ART appear to be limited in the B-cell compartment, with an incomplete reduction of total IgG levels and no recovery of IgG2 depletion. A short ART period did not have significant effects on IgG abnormalities in women who interrupted treatment. (C) 2019 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/31499207; info:eu-repo/semantics/altIdentifier/wos/WOS:000493901000001; volume:88; firstpage:1; lastpage:7; numberofpages:7; journal:INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES; http://hdl.handle.net/2108/232593Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85072565373 |
| DOI: | 10.1016/j.ijid.2019.09.001 |
| الإتاحة: | https://doi.org/10.1016/j.ijid.2019.09.001Test http://hdl.handle.net/2108/232593Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.175E7AFC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ijid.2019.09.001 |
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