دورية أكاديمية
Prognostic significance of performing universal HER2 testing in cases of advanced gastric cancer.
| العنوان: | Prognostic significance of performing universal HER2 testing in cases of advanced gastric cancer. |
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| المؤلفون: | Jiménez-Fonseca, Paula, Carmona-Bayonas, Alberto, Sánchez Lorenzo, Maria Luisa, Plazas, Javier Gallego, Custodio, Ana, Hernández, Raquel, Garrido, Marcelo, García, Teresa, Echavarría, Isabel, Cano, Juana María, Rodríguez Palomo, Alberto, Mangas, Monserrat, Macías Declara, Ismael, Ramchandani, Avinash, Visa, Laura, Viudez, Antonio, Buxó, Elvira, Díaz-Serrano, Asunción, López, Carlos, Azkarate, Aitor, Longo, Federico, Castañón, Eduardo, Sánchez Bayona, Rodrigo, Pimentel, Paola, Limón, Maria Luisa, Cerdá, Paula, Álvarez Llosa, Renata, Serrano, Raquel, Lobera, Maria Pilar Felices, Alsina, María, Hurtado Nuño, Alicia, Gómez-Martin, Carlos |
| سنة النشر: | 2016 |
| المجموعة: | Sistema Sanitario Público de Andalucía (SSPA): Repositorio |
| مصطلحات موضوعية: | Gastric cancer, HER2 testing, Personalized medicine, Quality of care, Trastuzumab, Adult, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Prognosis, Proportional Hazards Models, Receptor, ErbB-2, Spain, Stomach Neoplasms |
| الوصف: | Trastuzumab significantly improves overall survival (OS) when added to cisplatin and fluoropyrimidine as a treatment for HER2-positive advanced gastric cancers (AGC). The aim of this study was to evaluate the impact of the gradual implementation of HER2 testing on patient prognosis in a national registry of AGC. This Spanish National Cancer Registry includes cases who were consecutively recruited at 28 centers from January 2008 to January 2016. The effect of missing HER2 status was assessed using stratified Cox proportional hazards (PH) regression. The rate of HER2 testing increased steadily over time, from 58.3 % in 2008 to 92.9 % in 2016. HER2 was positive in 194 tumors (21.3 %). In the stratified Cox PH regression, each 1 % increase in patients who were not tested for HER2 at the institutions was associated with an approximately 0.3 % increase in the risk of death: hazard ratio, 1.0035 (CI 95 %, 1.001-1.005), P = 0.0019. Median OS was significantly lower at institutions with the highest proportions of patients who were not tested for HER2. Patients treated at centers that took longer to implement HER2 testing exhibited worse clinical outcomes. The speed of implementation behaves as a quality-of-care indicator. Reviewed guidelines on HER2 testing should be used to achieve this goal in a timely manner. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1436-3305 |
| العلاقة: | http://hdl.handle.net/10668/10422Test; https://link.springer.com/content/pdf/10.1007/s10120-016-0639-8.pdfTest |
| DOI: | 10.1007/s10120-016-0639-8 |
| DOI: | 10.1007/s10120-016-0639-8.pdf |
| الإتاحة: | https://doi.org/10.1007/s10120-016-0639-8Test http://hdl.handle.net/10668/10422Test |
| حقوق: | open access |
| رقم الانضمام: | edsbas.175E7540 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14363305 |
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| DOI: | 10.1007/s10120-016-0639-8 |