التفاصيل البيبلوغرافية
| العنوان: |
Abnormality of Resting-State Functional Connectivity in Major Depressive Disorder: A Study With Whole-Head Near-Infrared Spectroscopy |
| المؤلفون: |
Eisuke Sakakibara, Yoshihiro Satomura, Jun Matsuoka, Shinsuke Koike, Naohiro Okada, Hanako Sakurada, Mika Yamagishi, Norito Kawakami, Kiyoto Kasai |
| المصدر: |
Frontiers in Psychiatry, Vol 12 (2021) |
| بيانات النشر: |
Frontiers Media S.A. |
| سنة النشر: |
2021 |
| مصطلحات موضوعية: |
major depressive disorder, resting-state functional connectivity, near-infrared spectroscopy, cognitive control network, partial correlation analysis, Psychiatry, RC435-571, psy, socio |
| الوصف: |
Near-infrared spectroscopy (NIRS) is a functional neuroimaging modality that has advantages in clinical usage. Previous functional magnetic resonance imaging (fMRI) studies have found that the resting-state functional connectivity (RSFC) of the default mode network (DMN) is increased, while the RSFC of the cognitive control network (CCN) is reduced in patients with major depressive disorder (MDD) compared with healthy controls. This study tested whether the NIRS-based RSFC measurements can detect the abnormalities in RSFC that have been associated with MDD in previous fMRI studies. We measured 8 min of resting-state brain activity in 34 individuals with MDD and 78 age- and gender-matched healthy controls using a whole-head NIRS system. We applied a previously established partial correlation analysis for estimating RSFCs between the 17 cortical regions. We found that MDD patients had a lower RSFC between the left dorsolateral prefrontal cortex and the parietal lobe that comprise the CCN, and a higher RSFC between the right orbitofrontal cortex and ventrolateral prefrontal cortex, compared to those in healthy controls. The RSFC strength of the left CCN was negatively correlated with the severity of depressive symptoms and the dose of antipsychotic medication and positively correlated with the level of social functioning. The results of this study suggest that NIRS-based measurements of RSFCs have potential clinical applications. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
https://doi.org/10.3389/fpsyt.2021.664859Test |
| DOI: |
10.3389/fpsyt.2021.664859 |
| الإتاحة: |
https://doi.org/10.3389/fpsyt.2021.664859Test |
| حقوق: |
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| رقم الانضمام: |
edsbas.172C61B0 |
| قاعدة البيانات: |
BASE |
