دورية أكاديمية
The impact of targeted malaria elimination with mass drug administrations on falciparum malaria in Southeast Asia: A cluster randomised trial
| العنوان: | The impact of targeted malaria elimination with mass drug administrations on falciparum malaria in Southeast Asia: A cluster randomised trial |
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| المؤلفون: | von Seidlein, Lorenz, Peto, Thomas, J, Landier, Jordi, Nguyen, Thuy-Nhien, Tripura, Rupam, Phommasone, Koukeo, Pongvongsa, Tiengkham, Lwin, Khin, Maung, Keereecharoen, Lilly, Kajeechiwa, Ladda, Thwin, May, Myo, Parker, Daniel, M, Wiladphaingern, Jacher, Nosten, Suphak, Proux, Stephane, Corbel, Vincent, Tuong-Vy, Nguyen, Le Phuc-Nhi, Truong, Son, Do, Hung, Nguyen Huong-Thu, Pham, Tuyen, Nguyen Thi Kim, Tien, Nguyen, Thanh, Dong, Le, Thanh, van Hue, Dao, Quang, Huynh Hong, Nguon, Chea, Davoeung, Chan, Rekol, Huy, Adhikariid, Bipin, Henriques, Gisela, Phongmany, Panom, Suangkanarat, Preyanan, Jeeyapant, Atthanee, Vihokhern, Benchawan, van Der Pluijm, Rob, W, Lubell, Yoel, White, Lisa, J, Aguas, Ricardo, Promnarate, Cholrawee, Sirithiranont, Pasathorn, Malleret, Benoit, Rénia, Laurent, Onsjö, Carl, Chan, Xin, Hui, Chalk, Jeremy, Miotto, Olivo, Patumrat, Krittaya, Chotivanich, Kesinee, Hanboonkunupakarn, Borimas, Jittmala, Podjanee, Kaehler, Nils, Cheah, Phaik, Yeong, Pell, Christopher, Dhorda, Mehul, Imwong, Mallika, Snounou, Georges, Mukaka, Mavuto, Peerawaranun, Pimnara, Lee, Sue, J, Simpson, Julie, A, Pukrittayakamee, Sasithon, Singhasivanon, Pratap, Grobusch, Martin, P, Cobelens, Frank, Smithuis, Frank, Newton, Paul, N, Thwaites, Guy, E, Day, Nicholas, P J, Mayxay, Mayfong, Hien, Tran, Tinh, Nosten, Francois, H, Dondorp, Arjen, M, White, Nicholas, J |
| المساهمون: | Mahidol Oxford Tropical Medicine Research Unit (MORU), University of Oxford-Mahidol University Bangkok -Wellcome Trust, Centre for Tropical Medicine and Global Health Oxford, UK, Nuffield Department of Medicine Oxford, UK (Big Data Institute), University of Oxford-University of Oxford, Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Shoklo Malaria Research Unit Mae Sot, Thailand (SMRU), University of Oxford-Mahidol University Bangkok -Wellcome Trust-University of Oxford-Mahidol University Bangkok -Wellcome Trust, Oxford University Clinical Research Unit Ho Chi Minh City (OUCRU), Department of Infectious Diseases Amsterdam, Netherlands (Academic Medical Center), University of Amsterdam Amsterdam = Universiteit van Amsterdam (UvA)-Center for Tropical and Travel Medicine Amsterdam, Netherlands, Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Mahidol University Bangkok -Mahosot Hospital, Amsterdam Institute for Global Health & Development Amsterdam, The Netherlands, Savannakhet Provincial Health Department Lao People’s Democratic Republic, Savannakhet Province Lao People’s Democratic Republic, Department of Clinical Tropical Medicine Bangkok, Thailand (Faculty of Tropical Medicine), Mahidol University Bangkok, Department of Population Health and Disease Prevention Irvine, CA, USA, University of California Irvine (UC Irvine), University of California (UC)-University of California (UC), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD France-Sud ), Institute of Malariology, Parasitology, and Entomology Ho Chi Minh City, Vietnam (IMPE), Center for Malariology, Parasitology and Entomology Ninh Thuan Province, Vietnam (CMPE), Institute of Malariology, Parasitology, and Entomology Quy Nhon, Vietnam (IMPE), National Center for Parasitology, Entomology and Malaria Control Phnom Penh, Cambodia (CNM), Provincial Health Department Battambang, Cambodia (PHD), Department of Pathogen Molecular Biology London, UK, London School of Hygiene and Tropical Medicine (LSHTM), WWARN Asia Regional Centre Bangkok, Thailand, Department of Microbiology & Immunology Singapore (Yong Loo Lin School of Medicine), National University of Singapore (NUS), Singapore Immunology Network (SIgN), Biomedical Sciences Institute (BMSI), Department of Oncology, Clinical and Experimental Medicine, Faculty of Health Sciences Linköping University, Linköping University (LIU), Wellcome Trust Sanger Institute Hinxton, UK, Department of Molecular Tropical Medicine and Genetics Bangkok, Thailand (Faculty of Tropical Medicine), Department of Tropical Hygiene Bangkok, Thailand (Faculty of Tropical Medicine), Immunologie des Maladies Virales et Autoimmunes (IMVA - U1184), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre for Epidemiology and Biostatistics Victoria, Australia, University of Melbourne-Melbourne School of Population and Global Health Victoria, Australia, Royal Society of Thailand Bangkok, Thailand, Myanmar Oxford Clinical Research Unit Yangon, Myanmar, Institute of Research and Education Development Vientiane, Lao People’s Democratic Republic, University of Health Sciences Vientiane, Laos (UHS), NJW is the recipient of the Wellcome Trust Award Number: 101148/Z/13/Z. AMD is the recipient of the Bill and Melinda Gates Foundation Award Number: OPP1081420. JAS is the recipient of the National Health and Medical Research Council Award Number: 1104975. |
| المصدر: | ISSN: 1549-1277. |
| بيانات النشر: | HAL CCSD Public Library of Science |
| سنة النشر: | 2019 |
| المجموعة: | Université de Montpellier: HAL |
| مصطلحات موضوعية: | [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases |
| الوصف: | International audience ; BACKGROUND:The emergence and spread of multidrug-resistant Plasmodium falciparum in the Greater Mekong Subregion (GMS) threatens global malaria elimination efforts. Mass drug administration (MDA), the presumptive antimalarial treatment of an entire population to clear the subclinical parasite reservoir, is a strategy to accelerate malaria elimination. We report a cluster randomised trial to assess the effectiveness of dihydroartemisinin-piperaquine (DP) MDA in reducing falciparum malaria incidence and prevalence in 16 remote village populations in Myanmar, Vietnam, Cambodia, and the Lao People's Democratic Republic, where artemisinin resistance is prevalent.METHODS AND FINDINGS:After establishing vector control and community-based case management and following intensive community engagement, we used restricted randomisation within village pairs to select 8 villages to receive early DP MDA and 8 villages as controls for 12 months, after which the control villages received deferred DP MDA. The MDA comprised 3 monthly rounds of 3 daily doses of DP and, except in Cambodia, a single low dose of primaquine. We conducted exhaustive cross-sectional surveys of the entire population of each village at quarterly intervals using ultrasensitive quantitative PCR to detect Plasmodium infections. The study was conducted between May 2013 and July 2017. The investigators randomised 16 villages that had a total of 8,445 residents at the start of the study. Of these 8,445 residents, 4,135 (49%) residents living in 8 villages, plus an additional 288 newcomers to the villages, were randomised to receive early MDA; 3,790 out of the 4,423 (86%) participated in at least 1 MDA round, and 2,520 out of the 4,423 (57%) participated in all 3 rounds. The primary outcome, P. falciparum prevalence by month 3 (M3), fell by 92% (from 5.1% [171/3,340] to 0.4% [12/2,828]) in early MDA villages and by 29% (from 7.2% [246/3,405] to 5.1% [155/3,057]) in control villages. Over the following 9 months, the P. falciparum ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/30768615; inserm-02143366; https://inserm.hal.science/inserm-02143366Test; https://inserm.hal.science/inserm-02143366/documentTest; https://inserm.hal.science/inserm-02143366/file/journal.pmed.1002745.pdfTest; IRD: fdi:010075280; PUBMED: 30768615; PUBMEDCENTRAL: PMC6377128 |
| DOI: | 10.1371/journal.pmed.1002745 |
| الإتاحة: | https://doi.org/10.1371/journal.pmed.1002745Test https://inserm.hal.science/inserm-02143366Test https://inserm.hal.science/inserm-02143366/documentTest https://inserm.hal.science/inserm-02143366/file/journal.pmed.1002745.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.16DAD303 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pmed.1002745 |
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