دورية أكاديمية
Mitochondrial quality control turns out to be the principal suspect in parkin and PINK1-related autosomal recessive Parkinson's disease. ; : Mitochondrial quality control mechanisms
| العنوان: | Mitochondrial quality control turns out to be the principal suspect in parkin and PINK1-related autosomal recessive Parkinson's disease. ; : Mitochondrial quality control mechanisms |
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| المؤلفون: | Corti, Olga, Brice, Alexis |
| المساهمون: | Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut national de la santé et de la recherche médicale, Association France Parkinson, Fondation de France, Agence Nationale de la Recherche, MEFOPA (funded by the EU 7th Framework Programme, Grant Agreement HEALTH-2009-241791), Fondation ICM, the French Ministry of Higher Education and Research, "Investissements d'avenir" ANR-10-IAIHU-06., European Project: 241791,HEALTH,FP7-HEALTH-2009-single-stage,MEFOPA(2010) |
| المصدر: | ISSN: 0959-4388 ; Current Opinion in Neurobiology ; https://inserm.hal.science/inserm-00876368Test ; Current Opinion in Neurobiology, 2013, 23 (1), pp.100-108. ⟨10.1016/j.conb.2012.11.002⟩. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | MESH: Animals Humans Mitochondria/genetics Mitochondria/metabolism* Parkinson Disease/genetics Parkinson Disease/metabolism Parkinson Disease/physiopathology* Protein Kinases/genetics Protein Kinases/metabolism* Ubiquitin-Protein Ligases/genetics Ubiquitin-Protein Ligases/metabolism, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] |
| الوصف: | International audience ; Mitochondrial dysfunction has long been suspected to play a key role in neurodegeneration in Parkinson's disease. PINK1 and Parkin, the products of two genes responsible for autosomal recessive Parkinsonian syndromes with early onset, act as a quality control system on the outer mitochondrial membrane to preserve mitochondrial integrity. While doing so, they interact with multiple molecular actors in processes regulating mitochondrial biology and cell survival. The physiological conditions that mobilize these processes in neurons, and the mechanisms underlying their integration and spatiotemporal coordination, remain to be elucidated. Understanding how dysfunction of these house-keeping pathways leads to the preferential degeneration of a specific neuronal population in Parkinson's disease is a major challenge for future research |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/23206589; info:eu-repo/grantAgreement//241791/EU/European Project on Mendelian Forms of Parkinson's Disease/MEFOPA; inserm-00876368; https://inserm.hal.science/inserm-00876368Test; https://inserm.hal.science/inserm-00876368/documentTest; https://inserm.hal.science/inserm-00876368/file/Corti_Brice_Revised_Figure_2.pdfTest; https://inserm.hal.science/inserm-00876368/file/Corti_Brice_Revised_Figure_1.pdfTest; https://inserm.hal.science/inserm-00876368/file/Corti_Brice_Revised_Highlights.pdfTest; https://inserm.hal.science/inserm-00876368/file/Corti_Brice_Revised_Manuscript.pdfTest; PUBMED: 23206589 |
| DOI: | 10.1016/j.conb.2012.11.002 |
| الإتاحة: | https://doi.org/10.1016/j.conb.2012.11.002Test https://inserm.hal.science/inserm-00876368Test https://inserm.hal.science/inserm-00876368/documentTest https://inserm.hal.science/inserm-00876368/file/Corti_Brice_Revised_Figure_2.pdfTest https://inserm.hal.science/inserm-00876368/file/Corti_Brice_Revised_Figure_1.pdfTest https://inserm.hal.science/inserm-00876368/file/Corti_Brice_Revised_Highlights.pdfTest https://inserm.hal.science/inserm-00876368/file/Corti_Brice_Revised_Manuscript.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.16BF57B6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.conb.2012.11.002 |
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