دورية أكاديمية
The role of chest CT in deciphering interstitial lung involvement: systemic sclerosis versus COVID-19
| العنوان: | The role of chest CT in deciphering interstitial lung involvement: systemic sclerosis versus COVID-19 |
|---|---|
| المؤلفون: | Orlandi, M, Landini, N, Sambataro, G, Nardi, C, Tofani, L, Bruni, C, Bellando-Randone, S, Blagojevic, J, Melchiorre, D, Hughes, M, Denton, CP, Luppi, F, Ruaro, B, Della Casa, F, Rossi, FW, De Luca, G, Campochiaro, C, Spinicci, M, Zammarchi, L, Tomassetti, S, Caminati, A, Cavigli, E, Albanesi, M, Melchiorre, F, Palmucci, S, Vegni, V, Guiducci, S, Moggi-Pignone, A, Allanore, Y, Bartoloni, A, Confalonieri, M, Dagna, L, De Cobelli, F, De Paulis, A, Harari, S, Khanna, D, Kuwana, M, Taliani, G, Lavorini, F, Miele, V, Morana, G, Pesci, A, Vancheri, C, Colagrande, S, Matucci-Cerinic, M |
| المصدر: | Rheumatology , 61 (4) pp. 1600-1609. (2022) |
| سنة النشر: | 2022 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | COVID-19, COVID-19 pneumonia, interstitial lung disease, lung CT scan, systemic sclerosis |
| الوصف: | Objective: The aim of this study was to identify the main CT features that may help in distinguishing a progression of interstitial lung disease (ILD) secondary to SSc from COVID-19 pneumonia. // Methods: This multicentric study included 22 international readers grouped into a radiologist group (RADs) and a non-radiologist group (nRADs). A total of 99 patients, 52 with COVID-19 and 47 with SSc-ILD, were included in the study. // Results: Fibrosis inside focal ground-glass opacities (GGOs) in the upper lobes; fibrosis in the lower lobe GGOs; reticulations in lower lobes (especially if bilateral and symmetrical or associated with signs of fibrosis) were the CT features most frequently associated with SSc-ILD. The CT features most frequently associated with COVID- 19 pneumonia were: consolidation (CONS) in the lower lobes, CONS with peripheral (both central/peripheral or patchy distributions), anterior and posterior CONS and rounded-shaped GGOs in the lower lobes. After multivariate analysis, the presence of CONs in the lower lobes (P < 0.0001) and signs of fibrosis in GGOs in the lower lobes (P < 0.0001) remained independently associated with COVID-19 pneumonia and SSc-ILD, respectively. A predictive score was created that was positively associated with COVID-19 diagnosis (96.1% sensitivity and 83.3% specificity). // Conclusion: CT diagnosis differentiating between COVID-19 pneumonia and SSc-ILD is possible through a combination of the proposed score and radiologic expertise. The presence of consolidation in the lower lobes may suggest COVID-19 pneumonia, while the presence of fibrosis inside GGOs may indicate SSc-ILD. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | https://discovery.ucl.ac.uk/id/eprint/10135612/1/CT%20SSc%20covid%20for%20UCL%20upload%202021.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10135612Test/ |
| الإتاحة: | https://discovery.ucl.ac.uk/id/eprint/10135612/1/CT%20SSc%20covid%20for%20UCL%20upload%202021.pdfTest https://discovery.ucl.ac.uk/id/eprint/10135612Test/ |
| حقوق: | open |
| رقم الانضمام: | edsbas.1667C233 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |