دورية أكاديمية
DETERMINAÇÃO VOLTAMÉTRICA SIMULTÂNEA DE BESILATO DE ANLODIPINO E HIDROCLOROTIAZIDA EM AMOSTRAS DE URINA SINTÉTICA UTILIZANDO UM ELETRODO DE DIAMANTE DOPADO COM BORO
| العنوان: | DETERMINAÇÃO VOLTAMÉTRICA SIMULTÂNEA DE BESILATO DE ANLODIPINO E HIDROCLOROTIAZIDA EM AMOSTRAS DE URINA SINTÉTICA UTILIZANDO UM ELETRODO DE DIAMANTE DOPADO COM BORO |
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| المؤلفون: | Laís Pereira Silva, Bruna C. Lourencao, Orlando Fatibello-Filho |
| المصدر: | Química Nova, Vol 38, Iss 6, Pp 801-806 (2015) |
| بيانات النشر: | Sociedade Brasileira de Química |
| سنة النشر: | 2015 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | antihypertensive, amlodipine besylate, hydrochlorothiazide, BDD, square-wave voltammetry, Chemistry, QD1-999 |
| الوصف: | A novel method for simultaneous voltammetric determination of the antihypertensive drugs, amlodipine besylate (AML) and hydrochlorothiazide (HTZ) in synthetic urine samples was developed. Determination was carried out with a cathodically pretreated boron-doped diamond electrode (CPT-BDD) using square-wave voltammetry (SWV) and Britton-Robinson buffer solution at pH 2 as the supporting electrolyte. AML and HTZ exhibited oxidation peaks at 0.88 V and 1.30 V, respectively. The difference in potentials of 0.42 V allowed the simultaneous determination of these two analytes. The analytical curve showed linear response in the concentration range from 0.200 to 9.09 µmol L -1 for AML and from 4.00 to 100 µmol L -1 for HTZ, with a limit of detection (LOD) of 60.0 nmol L -1 and of 2.00 µmol L -1 for AML and HTZ, respectively. Recoveries of these analytes ranged from 91.0 to 107%. The proposed method using SWV and a CPT-BDD electrode is simple, fast and low cost, representing a good alternative for simultaneous determination of AML and HTZ in urine samples. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English Spanish; Castilian Portuguese |
| تدمد: | 1678-7064 |
| العلاقة: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422015000600801&lng=en&tlng=enTest; https://doaj.org/toc/1678-7064Test; https://doaj.org/article/a71cbc04b79b44dba5a36ff1172eed61Test |
| DOI: | 10.5935/0100-4042.20150077 |
| الإتاحة: | https://doi.org/10.5935/0100-4042.20150077Test https://doaj.org/article/a71cbc04b79b44dba5a36ff1172eed61Test |
| رقم الانضمام: | edsbas.1641B414 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16787064 |
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| DOI: | 10.5935/0100-4042.20150077 |