التفاصيل البيبلوغرافية
| العنوان: |
Prenatal exposure to ambient air pollution and the risk of preterm birth and stillbirth:synergy among air pollutants in causing preterm birth |
| المؤلفون: |
Siddika, N. (Nazeeba) |
| المساهمون: |
Jaakkola, J. (Jouni J. K.), Amegah, A. (Adeladza K.) |
| بيانات النشر: |
Oulun yliopisto |
| سنة النشر: |
2020 |
| المجموعة: |
Jultika - University of Oulu repository / Oulun yliopiston julkaisuarkisto |
| مصطلحات موضوعية: |
air pollution, fine particulates, interaction, nitrogen dioxide, ozone, prenatal exposure, preterm birth, stillbirth, ennenaikainen synnytys, ilmansaasteet, kohtukuolema, otsoni, pienhiukkaset, raskaudenaikainen altistus, typpidioksidi, yhteisvaikutus |
| الوصف: |
Previous studies provided little evidence related to low-level air pollution exposure on the risk of preterm birth (PTB). Epidemiologic studies on the synergistic effects of different air pollutants on the risk of PTB are scarce. In addition, the evidence from initial studies of prenatal exposure to ambient air pollution and stillbirth is equivocal. This project assessed the independent and joint effects of prenatal exposure to ambient air pollution on the risk of PTB, and summarized the existing evidence on the relationship between ambient air pollution and the risk of stillbirth through a systematic review and meta-analysis. The study population comprised 2,568 members of the Espoo Cohort Study, born between 1984 and 1990, living in Espoo, Finland. Individual-level ambient air pollution concentrations were assessed by using dispersion modelling and the land-use regression-based method. PubMed, Scopus and Web of Science databases were searched for studies investigating air pollution and stillbirth. Results show that the joint effect of PM2.5 and O3 exposure during the entire pregnancy (long-term) was substantially higher with an adjusted RR of 3.63 (95% CI: 2.16, 6.10), than what would have been expected from their independent effects (0.99 for PM2.5 and 1.34 for O3) and the relative excess risk due to interaction (RERI) was 2.30 (95% CI: 0.95, 4.57). This indicates long-term exposure to PM2.5 and O3 may act synergistically potentiating each other’s adverse effects on the risk of PTB. The highest levels of exposure to PM2.5, PM10 and NO2 in the week just before delivery (short-term) were related to 67% (95% CI: 14%, 146%), 60% (95%CI: 9%, 134%) and 65% (95% CI: 14%, 137%) increased in the risk of PTB, respectively. There were no significant joint effects of different air pollutant exposure during the week prior to the delivery (short-term) on the risk of PTB. The meta-analysis indicated that prenatal exposure to ambient air pollution increased the risk of stillbirth. In order to prevent ambient air ... |
| نوع الوثيقة: |
doctoral or postdoctoral thesis |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
info:eu-repo/semantics/altIdentifier/pissn/0355-3221; info:eu-repo/semantics/altIdentifier/eissn/1796-2234 |
| الإتاحة: |
http://urn.fi/urn:isbn:9789526227252Test |
| حقوق: |
info:eu-repo/semantics/openAccess ; © University of Oulu, 2020 |
| رقم الانضمام: |
edsbas.161590CA |
| قاعدة البيانات: |
BASE |
