دورية أكاديمية
Diversification of human plasmacytoid predendritic cells in response to a single stimulus
| العنوان: | Diversification of human plasmacytoid predendritic cells in response to a single stimulus |
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| المؤلفون: | Alculumbre, Solana, Saint-André, Violaine, Di Domizio, Jérémy, Vargas, Pablo, Sirven, Philemon, Bost, Pierre, Maurin, Mathieu, L, Maiuri, Paolo, Wery, Maxime, Roman, Mabel San, Savey, Léa, Touzot, Maxime, Terrier, Benjamin, Saadoun, David, Conrad, Curdin, Gilliet, Michel, Morillon, Antonin, Soumelis, Vassili |
| المساهمون: | Immunité et cancer (U932), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie Paris -Institut National de la Santé et de la Recherche Médicale (INSERM), Dynamique de l'information génétique : bases fondamentales et cancer (DIG CANCER), Institut Curie Paris -Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital Lausanne (CHUV), Biologie Cellulaire et Cancer, École normale supérieure - Paris (ENS-PSL), Université Paris Sciences et Lettres (PSL), Institut Curie Paris, IFOM, Istituto FIRC di Oncologia Molecolare (IFOM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut Curie Paris -Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), AURA Paris - Plaisance, Centre National de Référence Maladies Systémiques et Autoimmunes Rares, Hôpital Cochin AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CIC1428 IGR-CURIE, Institut Curie Paris -Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported by funding from INSERM (BIO2014-08), FRM, ANR-13-BSV1-0024-02, ANR-10-IDEX-0001-02 PSL* and ANR-11-LABX-0043, ERC (IT-DC 281987, HEALTH 2011-261366 and 2013/COG/616180 DARK) and CIC IGR-Curie 1428. S.G.A. was supported by an IC fellowship and LabEx DCbiol. V.S-A. is supported as a Fondation pour la Recherche Médicale fellow (ARF20150934193). High-throughput sequencing was performed by the ICGex NGS platform of the Institut Curie, supported by grants ANR-10-EQPX-03 (Equipex) and ANR-10-INBS-09-08 (France Génomique Consortium) from the Agence Nationale de la Recherche (‘Investissements d’Avenir’ program), by the Canceropole Ile-de-France and by the SiRIC-Curie program, SiRIC Grant INCa-DGOS-4654., We thank the Cytometry Core facility of IC for cell sorting. We thank INSERM U932, particularly P. Michea, for frequent discussions. We thank S. Amigorena, N. Manel and L. Pattarini for critical reading of the manuscript., ANR-10-INBS-0009,France Génomique,Organisation et montée en puissance d'une Infrastructure Nationale de Génomique(2010), ANR-10-EQPX-0003,ICGex,Equipement de biologie intégrative du cancer pour une médecine personnalisée(2010) |
| المصدر: | ISSN: 1529-2908. |
| بيانات النشر: | HAL CCSD Nature Publishing Group |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity |
| الوصف: | Comment in : Plasmacytoid dendritic cells: Division of labour./ Bird L. Nat Rev Immunol. 2017 Dec 22;18(1):2-3. doi:10.1038/nri.2017.153. PMID: 29269763 ; International audience ; Innate immune cells adjust to microbial and inflammatory stimuli through a process termed environmental plasticity, which links a given individual stimulus to a unique activated state. Here, we report that activation of human plasmacytoid predendritic cells (pDCs) with a single microbial or cytokine stimulus triggers cell diversification into three stable subpopulations (P1-P3). P1-pDCs (PD-L1+CD80-) displayed a plasmacytoid morphology and specialization for type I interferon production. P3-pDCs (PD-L1-CD80+) adopted a dendritic morphology and adaptive immune functions. P2-pDCs (PD-L1+CD80+) displayed both innate and adaptive functions. Each subpopulation expressed a specific coding- and long-noncoding-RNA signature and was stable after secondary stimulation. P1-pDCs were detected in samples from patients with lupus or psoriasis. pDC diversification was independent of cell divisions or preexisting heterogeneity within steady-state pDCs but was controlled by a TNF autocrine and/or paracrine communication loop. Our findings reveal a novel mechanism for diversity and division of labor in innate immune cells. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/29203862; hal-02349815; https://hal.science/hal-02349815Test; PUBMED: 29203862 |
| DOI: | 10.1038/s41590-017-0012-z |
| الإتاحة: | https://doi.org/10.1038/s41590-017-0012-zTest https://hal.science/hal-02349815Test |
| رقم الانضمام: | edsbas.1601062 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41590-017-0012-z |
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