دورية أكاديمية
Systematic Literature Review: Ability of the IBDQ-32 to Detect Meaningful Change in Ulcerative Colitis Health Indicators
| العنوان: | Systematic Literature Review: Ability of the IBDQ-32 to Detect Meaningful Change in Ulcerative Colitis Health Indicators |
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| المؤلفون: | Dubinsky, Marla, Rice, Alexander, Yarlas, Aaron, Hur, Peter, Cappelleri, Joseph C, Kulisek, Nicole, Fahrny, Audrey, Bushmakin, Andrew, Biedermann, Luc |
| المصدر: | Dubinsky, Marla; Rice, Alexander; Yarlas, Aaron; Hur, Peter; Cappelleri, Joseph C; Kulisek, Nicole; Fahrny, Audrey; Bushmakin, Andrew; Biedermann, Luc (2023). Systematic Literature Review: Ability of the IBDQ-32 to Detect Meaningful Change in Ulcerative Colitis Health Indicators. Inflammatory Bowel Diseases:Epub ahead of print. |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2023 |
| المجموعة: | University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
| مصطلحات موضوعية: | Clinic for Gastroenterology and Hepatology, 610 Medicine & health, Gastroenterology, Immunology and Allergy, IBDQ, responsiveness, ulcerative colitis |
| الوصف: | Purpose: Previous reviews produced weak evidence regarding the responsiveness of the Inflammatory Bowel Disease Questionnaire (IBDQ-32) to changes in ulcerative colitis (UC) health indicators. This systematic review and meta-analysis provide an updated synthesis on IBDQ-32 responsiveness. Methods: A systematic literature review identified 11 articles reporting IBDQ-32 responder analyses in randomized control trials, which were included in a random effects meta-analysis, and 15 articles linking IBDQ-32 change to change in UC health indicators, which were summarized narratively. Meta-analysis compared differences between IBDQ-32 responder proportions in efficacious and nonefficacious treatment arms relative to placebo. Linear meta-regression examined the association of treatment efficacy and proportions of IBDQ-32 responders in active treatment compared with placebo. Results: Meta-analysis showed larger differences in IBDQ-32 response proportions between active treatment and placebo for efficacious treatments (pooled OR, 2.19; 95% CI, 1.83-2.63) than nonefficacious treatments (pooled OR, 1.21; 95% CI, 0.84-1.74; Cochran's Q[df = 1] = 8.26, P = .004). Meta-regression showed that the magnitude of treatment efficacy positively predicted IBDQ-32 response in active treatments relative to placebo (β = 0.21, P < .001). Moderate to strong correlations were found between change in IBDQ-32 and change in health indicators (eg, patient-reported measures, disease activity, endoscopic indices; correlations, 0.37-0.64 in absolute values). Patients achieving clinical response or remission showed greater change in IBDQ-32 total scores (range, 22.3-50.1 points) and more frequently met clinically meaningful thresholds on the IBDQ-32 than those not achieving clinical response or remission (all P < .05). Conclusions: The IBDQ-32 is responsive to changes in UC health indicators and disease activity, including in response to efficacious treatment (relative to placebo). |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1078-0998 |
| العلاقة: | https://www.zora.uzh.ch/id/eprint/257275/1/ZORA_izad282.pdfTest; info:pmid/38150386; urn:issn:1078-0998 |
| DOI: | 10.5167/uzh-257275 |
| DOI: | 10.1093/ibd/izad282 |
| الإتاحة: | https://doi.org/10.5167/uzh-25727510.1093/ibd/izad282Test https://www.zora.uzh.ch/id/eprint/257275Test/ https://www.zora.uzh.ch/id/eprint/257275/1/ZORA_izad282.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess ; Creative Commons: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) ; http://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: | edsbas.15D5C755 |
| قاعدة البيانات: | BASE |
| تدمد: | 10780998 |
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| DOI: | 10.5167/uzh-257275 |