دورية أكاديمية
α-Synuclein conformers reveal link to clinical heterogeneity of α-synucleinopathies.
| العنوان: | α-Synuclein conformers reveal link to clinical heterogeneity of α-synucleinopathies. |
|---|---|
| المؤلفون: | Schmitz, Matthias, Candelise, Niccolò, Canaslan, Sezgi, Altmeppen, Hermann C, Matschke, Jakob, Glatzel, Markus, Younas, Neelam, Zafar, Saima, Hermann, Peter, Zerr, Inga |
| المصدر: | Translational neurodegeneration 12(1), 12 (2023). doi:10.1186/s40035-023-00342-4 |
| بيانات النشر: | Biomed Central |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | info:eu-repo/classification/ddc/570, Humans, alpha-Synuclein: genetics, alpha-Synuclein: metabolism, Synucleinopathies: diagnosis, Synucleinopathies: genetics, Synucleinopathies: metabolism, Parkinson Disease: diagnosis, Parkinson Disease: genetics, Parkinson Disease: metabolism, Lewy Bodies: pathology, Multiple System Atrophy: diagnosis, Multiple System Atrophy: genetics, Multiple System Atrophy: pathology, α-synuclein, Protein strains, RT-QuIC, α-synucleinopathies, alpha-Synuclein |
| جغرافية الموضوع: | DE |
| الوصف: | α-Synucleinopathies, such as Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy, are a class of neurodegenerative diseases exhibiting intracellular inclusions of misfolded α-synuclein (αSyn), referred to as Lewy bodies or oligodendroglial cytoplasmic inclusions (Papp-Lantos bodies). Even though the specific cellular distribution of aggregated αSyn differs in PD and DLB patients, both groups show a significant pathological overlap, raising the discussion of whether PD and DLB are the same or different diseases. Besides clinical investigation, we will focus in addition on methodologies, such as protein seeding assays (real-time quaking-induced conversion), to discriminate between different types of α-synucleinopathies. This approach relies on the seeding conversion properties of misfolded αSyn, supporting the hypothesis that different conformers of misfolded αSyn may occur in different types of α-synucleinopathies. Understanding the pathological processes influencing the disease progression and phenotype, provoked by different αSyn conformers, will be important for a personalized medical treatment in future. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/pmid:36915212; info:eu-repo/semantics/altIdentifier/issn/2096-6466; info:eu-repo/semantics/altIdentifier/issn/2047-9158; https://pub.dzne.de/record/256605Test; https://pub.dzne.de/search?p=id:%22DZNE-2023-00357%22Test |
| الإتاحة: | https://doi.org/10.1186/s40035-023-00342-4Test https://pub.dzne.de/record/256605Test https://pub.dzne.de/search?p=id:%22DZNE-2023-00357%22Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.1538234D |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |