دورية أكاديمية
Does an extensive diagnostic workup for upfront resectable pancreatic cancer result in a delay which affects survival? Results from an international multicentre study
| العنوان: | Does an extensive diagnostic workup for upfront resectable pancreatic cancer result in a delay which affects survival? Results from an international multicentre study |
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| المؤلفون: | Russell, TB, Labib, PL, Denson, J, Ausania, F, Pando, E, Roberts, KJ, Kausar, A, Mavroeidis, VK, Marangoni, G, Thomasset, SC, Frampton, AE, Lykoudis, P, Maglione, M, Alhaboob, N, Bari, H, Smith, AM, Spalding, D, Srinivasan, P, Davidson, BR, Bhogal, RH, Croagh, D, Rajagopalan, A, Dominguez, I, Thakkar, R, Gomez, D, Silva, MA, Lapolla, P, Mingoli, A, Porcu, A, Perra, T, Shah, NS, Hamady, ZZR, Al-Sarrieh, B, Serrablo, A, Aroori, S |
| المصدر: | Annals of Hepato-Biliary-Pancreatic Surgery (AHBPS) , 27 (4) pp. 403-414. (2023) |
| بيانات النشر: | The Korean Association of Hepato-Biliary-Pancreatic Surgery |
| سنة النشر: | 2023 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | Endoscopic retrograde cholangiopancreatography, Magnetic resonance imaging, Pancreatic ductal carcinoma, Pancreaticoduodenectomy, X-ray computed tomography |
| الوصف: | Backgrounds/Aims: Pancreatoduodenectomy (PD) is recommended in fit patients with a carcinoma (PDAC) of the pancreatic head, and a delayed resection may affect survival. This study aimed to correlate the time from staging to PD with long-term survival, and study the impact of preoperative investigations (if any) on the timing of surgery. // Methods: Data were extracted from the Recurrence After Whipple’s (RAW) study, a multicentre retrospective study of PD outcomes. Only PDAC patients who underwent an upfront resection were included. Patients who received neoadjuvant chemo-/radiotherapy were excluded. Group A (PD within 28 days of most recent preoperative computed tomography [CT]) was compared to group B (> 28 days). // Results: A total of 595 patents were included. Compared to group A (median CT-PD time: 12.5 days, interquartile range: 6–21), group B (49 days, 39–64.5) had similar one-year survival (73% vs. 75%, p = 0.6), five-year survival (23% vs. 21%, p = 0.6) and median time-todeath (17 vs. 18 months, p = 0.8). Staging laparoscopy (43 vs. 29.5 days, p = 0.009) and preoperative biliary stenting (39 vs. 20 days, p < 0.001) were associated with a delay to PD, but magnetic resonance imaging (32 vs. 32 days, p = 0.5), positron emission tomography (40 vs. 31 days, p > 0.99) and endoscopic ultrasonography (28 vs. 32 days, p > 0.99) were not. // Conclusions: Although a treatment delay may give rise to patient anxiety, our findings would suggest this does not correlate with worse survival. A delay may be necessary to obtain further information and minimize the number of PD patients diagnosed with early disease recurrence. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | https://discovery.ucl.ac.uk/id/eprint/10183827/1/ahbps-27-4-403.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10183827Test/ |
| الإتاحة: | https://discovery.ucl.ac.uk/id/eprint/10183827/1/ahbps-27-4-403.pdfTest https://discovery.ucl.ac.uk/id/eprint/10183827Test/ |
| حقوق: | open |
| رقم الانضمام: | edsbas.150526B8 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |