دورية أكاديمية
Limonoids from Aphanamixis polystachya leaves and their interaction with Hsp90
| العنوان: | Limonoids from Aphanamixis polystachya leaves and their interaction with Hsp90 |
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| المؤلفون: | C. Muñoz Camero, A. Vassallo, M. De Leo, A. Temraz, N. De Tommasi, A. Braca |
| المساهمون: | Muñoz Camero, C., Vassallo, A., De Leo, M., Temraz, A., De Tommasi, N., Braca, A. |
| سنة النشر: | 2018 |
| المجموعة: | ARPI - Archivio della Ricerca dell'Università di Pisa |
| مصطلحات موضوعية: | Aphanamixis polystachya, Meliaceae, limonoids, Surface Plasmon Resonance, Hsp90 |
| الوصف: | A phytochemical study of n-hexane, CHCl3, and CHCl3-MeOH extracts of Aphanamixis polystachya leaves led to the isolation of ten compounds. Five of them turned out to be new natural compounds, including two mexicanolide-type (1, 2) and three polyoxyphragmalin-type (3–5) limonoids, together with two known andirobin-type limonoids (6, 7), and three phenolic derivatives. The structures of the new compounds were established on the basis of spectroscopic methods to be 8-hydro-14,15-en-cabralin (1), 3-deacetyl-8-hydro-cabralin-14,15-en-3-one (2), 20,22-dihydroxy-21,23-dimethoxytetrahydrofuran khayanolide A (3), 1-deacetyl-3-dehydroxy-3-oxokhaysenelide E (4), and meliaphanamixin A (5). All compounds were isolated for the first time from this species. The ability of the isolated limonoids to interact with the molecular chaperone Hsp90 was tested. Compounds 6 and 7 resulted the most active. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/29763943; info:eu-repo/semantics/altIdentifier/wos/WOS:000440378900017; volume:84; issue:12-13; firstpage:964; lastpage:970; numberofpages:7; journal:PLANTA MEDICA; http://hdl.handle.net/11568/941960Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85047136894; https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-0624-9538Test |
| DOI: | 10.1055/a-0624-9538 |
| الإتاحة: | https://doi.org/10.1055/a-0624-9538Test http://hdl.handle.net/11568/941960Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.14BEFA71 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1055/a-0624-9538 |
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