دورية أكاديمية
Lateralization in C-11-Metomidate PET and outcome of adrenalectomy in primary aldosteronism
| العنوان: | Lateralization in C-11-Metomidate PET and outcome of adrenalectomy in primary aldosteronism |
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| المؤلفون: | Isojärvi, Juhani, Viukari, Marianna, Pörsti, Ilkka, Leijon, Helena, Vesterinen, Tiina, Seppänen, Marko, Nevalainen, Pasi I., Matikainen, Niina |
| المساهمون: | Faculty of Medicine, Endokrinologian yksikkö, HUSLAB, Department of Pathology, University of Helsinki, HUS Abdominal Center, Clinicum, Helsinki University Hospital Area |
| بيانات النشر: | Wiley |
| سنة النشر: | 2023 |
| المجموعة: | Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: | C-11-Metomidate positron emission tomography, adrenal venous sampling, primary aldosteronism, subtype classification in primary aldosteronism, surgical outcome, PREVALENCE, HYPERTENSION, DIAGNOSIS, 3121 General medicine, internal medicine and other clinical medicine |
| الوصف: | Introduction Subtype classification method is essential when considering adrenalectomy as a possible treatment for primary aldosteronism. We aimed to retrospectively evaluate surgical outcomes of primary aldosteronism in patients who had undergone C-11-metomidate positron emission tomography (C-11-MTO-PET) for subtype classification. Methods Postoperative clinical and biochemical cure and histopathological diagnosis from biobank samples were retrospectively evaluated in 44 patients who had all undergone preoperative C-11-MTO-PET with or without adrenal venous sampling (AVS). We compared those operated based on C-11-MTO-PET alone and those with concordant or discordant lateralization in C-11-MTO-PET and AVS studies according to postoperative immunohistochemical findings and biochemical and clinical cure. Results Adrenalectomy side was based on C-11-MTO-PET alone in 14 cases and on AVS in 30 cases of whom 42 achieved complete and two partial biochemical cures. Among those who underwent AVS and were operated according to it, the two lateralization methods were concordant in 22 cases and discordant in 8 cases. Similar immunohistochemical profiles and cure rates were seen after C-11-MTO-PET alone or AVS-based operations. Respectively, those with concordant or discordant C-11-MTO-PET and AVS lateralization did not differ in surgical outcome. Together, we found errors of lateralization diagnostics with C-11-MTO-PET in 18% and with AVS in 3% among those eligible for adrenal surgery. Conclusions Outcomes of adrenalectomy based on clinically significant lateralization in C-11-MTO-PET alone correspond to those based on C-11-MTO-PET with concordant AVS lateralization. However, our results suggest that diagnosis of unilateral PA should be performed with caution with C-11-MTO-PET in case of discordant lateralization studies. ; Peer reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| ردمك: | 978-0-00-847232-0 0-00-847232-7 |
| العلاقة: | Helsinki University Hospital, Grant/Award Number: TYH2020402 and VTR TYH2018111; Isojärvi , J , Viukari , M , Pörsti , I , Leijon , H , Vesterinen , T , Seppänen , M , Nevalainen , P I & Matikainen , N 2022 , ' Lateralization in C-11-Metomidate PET and outcome of adrenalectomy in primary aldosteronism ' , Endocrinology, diabetes & metabolism , vol. 5 , no. 6 , 368 . https://doi.org/10.1002/edm2.368Test; ORCID: /0000-0003-2997-0337/work/127503359; ORCID: /0000-0003-0041-1240/work/127503871; 96fe7a4d-4b5e-4f81-a286-8ddd10345ef0; http://hdl.handle.net/10138/353682Test; 000847232700001 |
| الإتاحة: | http://hdl.handle.net/10138/353682Test |
| حقوق: | cc_by ; openAccess ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.1473680B |
| قاعدة البيانات: | BASE |
| ردمك: | 9780008472320 0008472327 |
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