التفاصيل البيبلوغرافية
| العنوان: |
The possible role of colligin/HSP47, a collagen-binding protein, in the pathogenesis of human and experimental fibrotic diseases |
| المؤلفون: |
Razzaque, M. S., Taguchi, T. |
| المصدر: |
Histology and Histopathology; Vol. 14 No. 4 (1999); 1189-1212 ; Histology and Histopathology; Vol. 14 Núm. 4 (1999); 1189-1212 ; 1699-5848 ; 0213-3911 |
| بيانات النشر: |
Histology and Histopathology |
| سنة النشر: |
2011 |
| المجموعة: |
Revistas Científicas de la Universidad de Murcia |
| مصطلحات موضوعية: |
colligin/heat shock protein 47, collagen, glomerulosclerosis, fibrosis, human, rat |
| الوصف: |
Colligin or heat shock protein 47 (HSP47) is a stress protein that resides in the endoplasmic reticulum and is thought to participate in intracellular processing, folding, assembly and secretion of procollagens. Irrespective of the tissue site and organ, induction of colliginlHSP47 expression is always noted during the process of fibrosis, particularly in and around the fibrotic lesions in both humans and experimental models. Its expression is highly tissue- and cell-specific, and restricted to mostly phenotypically altered collagenproducing cells. These observations suggest that upregulation of this collagen-specific chaperone-colliginl HSP47 may play an important role in the subsequent fibrotic process, possibly by regulating increased synthesis/assembly of collagens. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
https://revistas.um.es/hh/article/view/128231/119471Test; https://revistas.um.es/hh/article/view/128231Test |
| الإتاحة: |
https://revistas.um.es/hh/article/view/128231Test |
| رقم الانضمام: |
edsbas.146D6F41 |
| قاعدة البيانات: |
BASE |
