دورية أكاديمية
Phase I study of sorafenib combined with radiation therapy and temozolomide as first-line treatment of high-grade glioma
| العنوان: | Phase I study of sorafenib combined with radiation therapy and temozolomide as first-line treatment of high-grade glioma |
|---|---|
| المؤلفون: | Hottinger, A F, Ben Aissa, Assma, Espeli, Vittoria, Squiban, D, Dunkel, Nathalie, Vargas Gomez, Maria Isabel, Hundsberger, T, Mach, Nicolas, Schaller, Karl Lothard, Weber, D C, Bodmer, A, Dietrich, Pierre-Yves |
| المصدر: | ISSN: 0007-0920 ; British journal of cancer, vol. 110, no. 11 (2014) p. 2655-2661. |
| سنة النشر: | 2014 |
| المجموعة: | Université de Genève: Archive ouverte UNIGE |
| مصطلحات موضوعية: | info:eu-repo/classification/ddc/616.8, info:eu-repo/classification/ddc/616.0757, info:eu-repo/classification/ddc/616, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols/pharmacokinetics/therapeutic use/toxicity, Brain Neoplasms/mortality/therapy, Chemoradiotherapy, Dacarbazine/administration & dosage/analogs & derivatives, Disease-Free Survival, Female, Glioblastoma/mortality/therapy, Humans, Male, Maximum Tolerated Dose, Middle Aged, Niacinamide/administration & dosage/analogs & derivatives, Phenylurea Compounds/administration & dosage, Treatment Outcome |
| الوصف: | Sorafenib (Sb) is a multiple kinase inhibitor targeting both tumour cell proliferation and angiogenesis that may further act as a potent radiosensitizer by arresting cells in the most radiosensitive cell cycle phase. This phase I open-label, noncontrolled dose escalation study was performed to determine the safety and maximum tolerated dose (MTD) of Sb in combination with radiation therapy (RT) and temozolomide (TMZ) in 17 patients with newly diagnosed high-grade glioma. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/24786603; https://archive-ouverte.unige.ch/unige:90881Test; unige:90881 |
| الإتاحة: | https://doi.org/10.1038/bjc.2014.209Test https://archive-ouverte.unige.ch/unige:90881Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.1430C300 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |