دورية أكاديمية
Subretinal drusenoid deposits in the elderly in a population-based study (the Montrachet study)
| العنوان: | Subretinal drusenoid deposits in the elderly in a population-based study (the Montrachet study) |
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| المؤلفون: | Gabrielle, Pierre Henry, Seydou, Alassane, Arnould, Louis, Acar, Niyazi, Devilliers, Hervé, Baudin, Florian, Ben Ghezala, Inès, Binquet, Christine, Bron, Alain Marie, Creuzot Garcher, Catherine |
| المساهمون: | Centre des Sciences du Goût et de l'Alimentation Dijon (CSGA), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Institut National de la Santé et de la Recherche Médicale (INSERM), INRA, CNRS, Université de Bourgogne, Regional Council of Burgundy France (PARI Agrale 1), FEDER (European Funding for Regional Economic Development), French National Research Agency (ANR) under the “Investissements d'Avenir” program, ANR-11-LABX-0021-01-LipSTIC Labex., ANR-11-LABX-0021,Lipstic,Lipoprotéines et santé : prévention et traitement des maladies inflammatoires non vasculaires et du cancer(2011) |
| المصدر: | ISSN: 0146-0404. |
| بيانات النشر: | HAL CCSD Association for Research in Vision and Ophthalmology |
| سنة النشر: | 2019 |
| المجموعة: | Université de Bourgogne (UB): HAL |
| مصطلحات موضوعية: | [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs |
| الوصف: | International audience ; Purpose: The aim of this study was to investigate the prevalence of subretinal drusenoid deposits (SDD) and to identify associated factors in an elderly population. Methods: The participants of the population-based Montrachet study underwent an exhaustive ophthalmologic examination, including color fundus photography and macular spectral domain-optical coherence tomography (SD-OCT), coupled with infrared reflectance imaging. The presence of SDD and other age-related macular degeneration lesions, according to the European Eye Epidemiology SD-OCT classification of macular diseases, and subfoveal choroidal thickness were recorded. Moreover, the association of SDD and both clinical and demographic factors as well as plasma levels of vitamin E and lutein/zeaxanthin (L/Z) were analyzed. Results: The mean age of patients was 82.3 ± 3.8 years and 62.7% were female. The prevalence of SDD was 18.1% (n = 205) in the subjects with at least one eye interpretable (n = 1135). In multivariate analysis, SDD was positively associated with increasing age (OR, 4.6; 95% CI, 2.8–7.7; P < 0.001 for subjects aged >85 years), female sex (OR, 1.7; 95% CI, 1.2–2.4; P = 0.005), and plasma L/Z level (OR, 1.2; 95% CI, 1.0–1.5; P = 0.039), and negatively associated with lipid-lowering drugs use (OR, 0.5; 95% CI, 0.3–0.9; P = 0.014 for statin medications) and subfoveal choroidal thickness (OR, 0.8; 95% CI, 0.7–0.9; P = 0.002). Conclusions: The prevalence of SDD was high in subjects older than 75 years, more frequent in women, and was associated with a thinner choroid. The association with lipid-lowering drugs deserves further investigation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/31747683; hal-02622391; https://hal.inrae.fr/hal-02622391Test; https://hal.inrae.fr/hal-02622391/documentTest; https://hal.inrae.fr/hal-02622391/file/2019_gabrielle_iovs_1.pdfTest; https://hal.inrae.fr/hal-02622391/file/2019_gabrielle_suppl_iovs_2.pdfTest; PRODINRA: 489879; PUBMED: 31747683; WOS: 000500313300034 |
| DOI: | 10.1167/iovs.19-27283 |
| الإتاحة: | https://doi.org/10.1167/iovs.19-27283Test https://hal.inrae.fr/hal-02622391Test https://hal.inrae.fr/hal-02622391/documentTest https://hal.inrae.fr/hal-02622391/file/2019_gabrielle_iovs_1.pdfTest https://hal.inrae.fr/hal-02622391/file/2019_gabrielle_suppl_iovs_2.pdfTest |
| حقوق: | http://creativecommons.org/licenses/by-nc-ndTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.13F7C283 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1167/iovs.19-27283 |
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