دورية أكاديمية
In Vitro and In Silico Studies of Functionalized Polyurethane Surfaces toward Understanding Biologically Relevant Interactions
| العنوان: | In Vitro and In Silico Studies of Functionalized Polyurethane Surfaces toward Understanding Biologically Relevant Interactions |
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| المؤلفون: | Chytrosz-Wrobel, Paulina, Golda-Cepa, Monika, Drozdz, Kamil, Rysz, Jakub, Kubisiak, Piotr, Kulig, Waldemar, Brzychczy-Wloch, Monika, Cwiklik, Lukasz, Kotarba, Andrzej |
| المساهمون: | Department of Physics |
| بيانات النشر: | American Chemical Society |
| سنة النشر: | 2023 |
| المجموعة: | Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: | Bacteria adhesion, Biocompatibility, Moleculardynamics, Oxygen plasma, Polyurethane, 114 Physical sciences |
| الوصف: | The solid-aqueous boundary formed upon biomaterial implantation provides a playground for most biochemical reactions and physiological processes involved in implant-host interactions. Therefore, for biomaterial development, optimization, and application, it is essential to understand the biomaterial-water interface in depth. In this study, oxygen plasma-functionalized polyurethane surfaces that can be successfully utilized in contact with the tissue of the respiratory system were prepared and investigated. Through experiments, the influence of plasma treatment on the physicochemical properties of polyurethane was investigated by atomic force microscopy, attenuated total reflection infrared spectroscopy, differential thermal analysis, X-ray photoelectron spectroscopy, secondary ion mass spectrometry, and contact angle measurements, supplemented with biological tests using the A549 cell line and two bacteria strains (Staphylococcus aureus and Pseudomonas aeruginosa). The molecular interpretation of the experimental findings was achieved by molecular dynamics simulations employing newly developed, fully atomistic models of unmodified and plasma-functionalized polyurethane materials to characterize the polyurethane-water interfaces at the nanoscale in detail. The experimentally obtained polar and dispersive surface free energies were consistent with the calculated free energies, verifying the adequacy of the developed models. A 20% substitution of the polymeric chain termini by their oxidized variants was observed in the experimentally obtained plasma-modified polyurethane surface, indicating the surface saturation with oxygen-containing functional groups. ; Peer reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| ردمك: | 978-85-17-69739-5 85-17-69739-1 |
| العلاقة: | The authors thank the shared Czech-Polish research funding from the Czech Science Foundation (22-27317K) (MD force field and model development). This study was supported by the National Science Center, Poland, under grant no. DEC-2019/35/D/ST5/03107 (all the experiments). This research was supported, in part, by PLGrid Infrastructure. The authors wish to acknowledge the CSC-IT Center for Science (Espoo, Finland) for excellent computational resources.; Chytrosz-Wrobel , P , Golda-Cepa , M , Drozdz , K , Rysz , J , Kubisiak , P , Kulig , W , Brzychczy-Wloch , M , Cwiklik , L & Kotarba , A 2023 , ' In Vitro and In Silico Studies of Functionalized Polyurethane Surfaces toward Understanding Biologically Relevant Interactions ' , Acs Biomaterials Science & Engineering , vol. 9 , no. 11 , pp. 6112–6122 . https://doi.org/10.1021/acsbiomaterials.3c01367Test; ORCID: /0000-0001-7568-0029/work/148367890; 85176973914; 6f2fcde1-63ca-46cf-8047-980805f86c1f; http://hdl.handle.net/10138/568044Test; 001096714600001 |
| الإتاحة: | http://hdl.handle.net/10138/568044Test |
| حقوق: | cc_by ; openAccess ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.13D0E04C |
| قاعدة البيانات: | BASE |
| ردمك: | 9788517697395 8517697391 |
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