دورية أكاديمية
Cerebrospinal fluid dynamics in non-acute post-traumatic ventriculomegaly
| العنوان: | Cerebrospinal fluid dynamics in non-acute post-traumatic ventriculomegaly |
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| المؤلفون: | Lalou, Afroditi D., Levrini, Virginia, Czosnyka, Marek, Gergelé, Laurent, Garnett, Matthew, Kolias, Angelos, Hutchinson, Peter J., Czosnyka, Zofia |
| بيانات النشر: | BioMed Central Fluids and Barriers of the CNS |
| سنة النشر: | 2021 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | Research, Cerebrospinal fluid, CSF dynamics, CSF infusion test, Hydrocephalus, Traumatic brain injury, Ventriculomegaly |
| الوصف: | Background: Post-traumatic hydrocephalus (PTH) is potentially under-diagnosed and under-treated, generating the need for a more efficient diagnostic tool. We aim to report CSF dynamics of patients with post-traumatic ventriculomegaly. Materials and methods: We retrospectively analysed post-traumatic brain injury (TBI) patients with ventriculomegaly who had undergone a CSF infusion test. We calculated the resistance to CSF outflow (Rout), AMP (pulse amplitude of intracranial pressure, ICP), dAMP (AMPplateau-AMPbaseline) and compensatory reserve index correlation coefficient between ICP and AMP (RAP). To avoid confounding factors, included patients had to be non-decompressed or with cranioplasty > 1 month previously and Rout > 6 mmHg/min/ml. Compliance was assessed using the elasticity coefficient. We also compared infusion-tested TBI patients selected for shunting versus those not selected for shunting (consultant decision based on clinical and radiological assessment and the infusion results). Finally, we used data from a group of shunted idiopathic Normal Pressure Hydrocephalus (iNPH) patients for comparison. Results: Group A consisted of 36 patients with post-traumatic ventriculomegaly and Group B of 45 iNPH shunt responders. AMP and dAMP were significantly lower in Group A than B (0.55 ± 0.39 vs 1.02 ± 0.72; p < 0.01 and 1.58 ± 1.21 vs 2.76 ± 1.5; p < 0.01. RAP baseline was not significantly different between the two. Elasticity was higher than the normal limit in all groups (average 0.18 1/ml). Significantly higher Rout was present in those with probable PTH selected for shunting compared with unshunted. Mild/moderate hydrocephalus, ex-vacuo ventriculomegaly/encephalomalacia were inconsistently reported in PTH patients. Conclusions: Rout and AMP were significantly lower in PTH compared to iNPH and did not always reflect the degree of hydrocephalus or atrophy reported on CT/MRI. Compliance appears reduced in PTH. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf; text/xml |
| اللغة: | English |
| العلاقة: | https://www.repository.cam.ac.uk/handle/1810/319342Test |
| DOI: | 10.17863/CAM.66465 |
| الإتاحة: | https://doi.org/10.17863/CAM.66465Test https://www.repository.cam.ac.uk/handle/1810/319342Test |
| رقم الانضمام: | edsbas.1375C522 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17863/CAM.66465 |
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