دورية أكاديمية
Ferritin-mediated iron detoxification promotes hypothermia survival in Caenorhabditis elegans and murine neurons.
| العنوان: | Ferritin-mediated iron detoxification promotes hypothermia survival in Caenorhabditis elegans and murine neurons. |
|---|---|
| المؤلفون: | Pekec, Tina, Lewandowski, Jarosław, Komur, Alicja A, Sobańska, Daria, Guo, Yanwu, Świtońska-Kurkowska, Karolina, Małecki, Jędrzej M, Dubey, Abhishek Anil, Pokrzywa, Wojciech, Frankowski, Marcin, Figiel, Maciej, Ciosk, Rafal |
| المساهمون: | Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland, University of Basel, Faculty of Natural Sciences, Switzerland, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland, University of Oslo, Department of Biosciences, Norway, Laboratory of Protein Metabolism, International Institute of Molecular and Cell Biology, Warsaw, Poland, Adam Mickiewicz University in Poznań, Faculty of Chemistry, Poland |
| بيانات النشر: | Nature Publishing Group |
| سنة النشر: | 2022 |
| المجموعة: | Centre for Open Science: CeON Repository |
| الوصف: | How animals rewire cellular programs to survive cold is a fascinating problem with potential biomedical implications, ranging from emergency medicine to space travel. Studying a hibernation-like response in the free-living nematode Caenorhabditis elegans, we uncovered a regulatory axis that enhances the natural resistance of nematodes to severe cold. This axis involves conserved transcription factors, DAF-16/FoxO and PQM-1, which jointly promote cold survival by upregulating FTN-1, a protein related to mammalian ferritin heavy chain (FTH1). Moreover, we show that inducing expression of FTH1 also promotes cold survival of mammalian neurons, a cell type particularly sensitive to deterioration in hypothermia. Our findings in both animals and cells suggest that FTN-1/FTH1 facilitates cold survival by detoxifying ROS-generating iron species. We finally show that mimicking the effects of FTN-1/FTH1 with drugs protects neurons from cold-induced degeneration, opening a potential avenue to improved treatments of hypothermia. ; Project POIR.04.04.00-00-203 A/16 was carried out within the Team program of the Foundation for Polish Science, co-financed by the European Union under the European Regional Development Fund. RC was also supported by the EMBO Installation Grant No. 3615, the Polish National Science Center grant 2019/34/A/NZ3/00223, and the Research Council of Norway grant FRIMEDBIO-286499. The research leading to these results has received funding from the Norwegian Financial Mechanism 2014–2021 operated by the Polish National Science Center under the project contract nr UMO-2019/34/H/NZ3/00691. K.S.-K. and M.Fi. were supported by the National Science Center grant 2018/31/B/NZ3/03621 |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2041-1723 |
| العلاقة: | Pekec, T., Lewandowski, J., Komur, A.A. et al. Ferritin-mediated iron detoxification promotes hypothermia survival in Caenorhabditis elegans and murine neurons. Nat Commun 13, 4883 (2022). https://doi.org/10.1038/s41467-022-32500-zTest; https://www.nature.com/articles/s41467-022-32500-zTest; https://depot.ceon.pl/handle/123456789/21617Test |
| DOI: | 10.1038/s41467-022-32500-z |
| الإتاحة: | https://doi.org/10.1038/s41467-022-32500-zTest https://depot.ceon.pl/handle/123456789/21617Test https://www.nature.com/articles/s41467-022-32500-zTest |
| حقوق: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.1356CD01 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20411723 |
|---|---|
| DOI: | 10.1038/s41467-022-32500-z |