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Effect of sodium-glucose cotransporter type 2 inhibitors on non-alcoholic fatty liver disease ; Влияние ингибиторов натрий-глюкозного котранспортера 2-го типа на неалкогольную жировую болезнь печени

التفاصيل البيبلوغرافية
العنوان: Effect of sodium-glucose cotransporter type 2 inhibitors on non-alcoholic fatty liver disease ; Влияние ингибиторов натрий-глюкозного котранспортера 2-го типа на неалкогольную жировую болезнь печени
المؤلفون: L. A. Suplotovа, D. S. Kulmametova, A. I. Fedorova, T. S. Dushina, O. B. Makarova, Л. А. Суплотова, Д. С. Кульмаметова, А. И. Федорова, Т. С. Душина, О. Б. Макарова
المصدر: Meditsinskiy sovet = Medical Council; № 15 (2022); 83-89 ; Медицинский Совет; № 15 (2022); 83-89 ; 2658-5790 ; 2079-701X
بيانات النشر: REMEDIUM GROUP Ltd.
سنة النشر: 2022
المجموعة: Medical Council (E-Journal) / Медицинский Совет
مصطلحات موضوعية: гепатопротекция, sodium-glucose cotransporter type 2 inhibitors, metabolic syndrome, reducing body weight, hepatoprotection, ингибиторы натрий-глюкозного котранспортера 2-го типа, метаболический синдром, снижение массы тела
الوصف: Non-alcoholic fatty liver disease is one of the most common liver diseases, morphologically representing a whole spectrum of pathological conditions, from steatosis and steatohepatitis to fibrosis, the clinical outcomes of which can be liver cirrhosis and hepatocellular carcinoma. The frequency of adverse outcomes in the course of non-alcoholic fatty liver disease significantly increases against the background of type 2 diabetes mellitus, which is probably due to the pathogenetic synergy of non-alcoholic fatty liver disease and type 2 diabetes mellitus associated with metabolic syndrome. The commonality of pathogenetic links, as a result, suggests the unidirectionality of therapeutic approaches. In this connection, a search was made for studies and meta-analyses in large electronic databases (MEDLINE, Scopus, UpToDate, CyberLeninka) in order to study modern methods of pharmacotherapy for non-alcoholic fatty liver disease and type 2 diabetes mellitus. The results of a number of experimental and clinical studies evaluating the effect of hypoglycemic drugs of the group of sodium-glucose cotransporter type 2 inhibitors on non-alcoholic fatty liver disease demonstrate a wide range of intrahepatic effects that affect the manifestations of liver steatosis and fibrosis through the regulation of oxidative stress, endoplasmic reticulum stress, effects on intrahepatic inflammation, autophagy and apoptosis, as well as indirectly affecting hepatic metabolism, by reducing body weight. In addition, today gliflozins are rushing to occupy a completely new therapeutic niche, demonstrating anticarcinogenic effects in experimental studies. Thus, the pleiotropic effect of inhibitors of the sodium-glucose cotransporter type 2 suggests a potential hepatoprotective effect in the treatment of non-alcoholic fatty liver disease and its outcomes. ; Неалкогольная жировая болезнь печени является одним из наиболее распространенных заболеваний печени, морфологически представляя собой целый спектр патологических состояний, от стеатоза и ...
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: Russian
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DOI: 10.21518/2079-701X-2022-16-15-83-89
الإتاحة: https://doi.org/10.21518/2079-701X-2022-16-15-83-89Test
https://doi.org/10.26442/00403660.2022.02.201363Test
https://doi.org/10.3390/diagnostics11040689Test
https://doi.org/10.1007/s00535-013-0911-1Test
https://doi.org/10.1111/j.1365-2036.2005.02590.xTest
https://doi.org/10.1016/j.metabol.2020.154170Test
https://doi.org/10.1038/nrendo.2017.173Test
https://doi.org/10.1016/j.jhep.2006.06.013Test
https://doi.org/10.1016/j.jhep.2019.06.021Test
https://doi.org/10.1371/journal.pone.0178473Test
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رقم الانضمام: edsbas.134EEE5E
قاعدة البيانات: BASE
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DOI:10.21518/2079-701X-2022-16-15-83-89