دورية أكاديمية
NOX4-derived ROS are neuroprotective by balancing intracellular calcium stores
| العنوان: | NOX4-derived ROS are neuroprotective by balancing intracellular calcium stores |
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| المؤلفون: | Gola, Lukas, Bierhansl, Laura, Csatári, Júlia, Schroeter, Christina B., Korn, Lisanne, Narayanan, Venu, Cerina, Manuela, Abdolahi, Sara, Speicher, Anna, Hermann, Alexander M., König, Simone, Dinkova-Kostova, Albena T., Shekh-Ahmad, Tawfeeq, Meuth, Sven G., Wiendl, Heinz, Gorji, Ali, Pawlowski, Matthias, Kovac, Stjepana |
| المصدر: | Gola , L , Bierhansl , L , Csatári , J , Schroeter , C B , Korn , L , Narayanan , V , Cerina , M , Abdolahi , S , Speicher , A , Hermann , A M , König , S , Dinkova-Kostova , A T , Shekh-Ahmad , T , Meuth , S G , Wiendl , H , Gorji , A , Pawlowski , M & Kovac , S 2023 , ' NOX4-derived ROS are neuroprotective by balancing intracellular calcium stores ' , Cellular and Molecular Life Sciences , vol. 80 , no. .... |
| سنة النشر: | 2023 |
| المجموعة: | Discovery - University of Dundee Online Publications |
| مصطلحات موضوعية: | Calcium signaling, Hyperexcitability, Mitochondria, NADPH oxidase-4 (NOX4), Neurodegeneration, Reactive oxygen species (ROS), /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/3000/3004, name=Pharmacology, /dk/atira/pure/subjectarea/asjc/2800/2804, name=Cellular and Molecular Neuroscience, /dk/atira/pure/subjectarea/asjc/1300/1307, name=Cell Biology |
| الوصف: | Hyperexcitability is associated with neuronal dysfunction, cellular death, and consequently neurodegeneration. Redox disbalance can contribute to hyperexcitation and increased reactive oxygen species (ROS) levels are observed in various neurological diseases. NOX4 is an NADPH oxidase known to produce ROS and might have a regulating function during oxidative stress. We, therefore, aimed to determine the role of NOX4 on neuronal firing, hyperexcitability, and hyperexcitability-induced changes in neural network function. Using a multidimensional approach of an in vivo model of hyperexcitability, proteomic analysis, and cellular function analysis of ROS, mitochondrial integrity, and calcium levels, we demonstrate that NOX4 is neuroprotective by regulating ROS and calcium homeostasis and thereby preventing hyperexcitability and consequently neuronal death. These results implicate NOX4 as a potential redox regulator that is beneficial in hyperexcitability and thereby might have an important role in neurodegeneration. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://discovery.dundee.ac.uk/en/publications/19fada13-ac07-44ba-bd04-811947ccef2dTest |
| DOI: | 10.1007/s00018-023-04758-z |
| الإتاحة: | https://doi.org/10.1007/s00018-023-04758-zTest https://discovery.dundee.ac.uk/en/publications/19fada13-ac07-44ba-bd04-811947ccef2dTest https://discovery.dundee.ac.uk/ws/files/101662069/s00018_023_04758_z.pdfTest http://www.scopus.com/inward/record.url?scp=85153444985&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.1342C4DD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00018-023-04758-z |
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