دورية أكاديمية
Spatio-temporal dynamics of asymptomatic malaria : bridging the gap between annual malaria resurgences in a Sahelian environment
| العنوان: | Spatio-temporal dynamics of asymptomatic malaria : bridging the gap between annual malaria resurgences in a Sahelian environment |
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| المؤلفون: | Coulibaly, Drissa, Travassos, Mark, Tolo, Youssouf, Laurens, Matthew, Koné, Abdoulaye, Traore, Karim, Sissoko, Mody, Niangaly, Amadou, Diarra, Issa, Daou, Modibo, Guindo, Boureima, Rebaudet, Stanislas, Kouriba, Bourema, Dessay, Nadine, Piarroux, Renaud, Plowe, Christopher, V, Doumbo, Ogobara, Thera, Mahamadou, Ali, Gaudart, Jean |
| المساهمون: | Département d'Epidémiologie des Affections parasitaires, Malaria Research and training center Université de Bamako, Mali, Université de Bamako, Université Cheikh Anta Diop de Dakar Sénégal (UCAD), Institut des Maladies Emergentes et des Thérapies Innovantes (IMETI), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Aix Marseille Université (AMU), Assistance Publique - Hôpitaux de Marseille (APHM), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Malaria Research and Training Center (MRTC), Faculté de Médecine de Bamako, UMR 228 Espace-Dev, Espace pour le développement, Institut de Recherche pour le Développement (IRD)-Université de Perpignan Via Domitia (UPVD)-Avignon Université (AU)-Université de La Réunion (UR)-Université de Montpellier (UM)-Université de Guyane (UG)-Université des Antilles (UA), Malaria Research and Training Centre, Université de Bamako-Faculty of Medicine, Pharmacy, Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U912 INSERM - Aix Marseille Univ - IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| المصدر: | ISSN: 0002-9637 ; American Journal of Tropical Medicine and Hygiene ; https://ird.hal.science/ird-01630569Test ; American Journal of Tropical Medicine and Hygiene, 2017, 20 p. ⟨10.4269/ajtmh.17-0074⟩. |
| بيانات النشر: | HAL CCSD American Society of Tropical Medicine and Hygiene |
| سنة النشر: | 2017 |
| المجموعة: | HAL-CEA (Commissariat à l'énergie atomique et aux énergies alternatives) |
| مصطلحات موضوعية: | [SDE.ES]Environmental Sciences/Environment and Society, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment, [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], [SDE.MCG]Environmental Sciences/Global Changes, [SCCO.COMP]Cognitive science/Computer science, [SDU.STU.CL]Sciences of the Universe [physics]/Earth Sciences/Climatology, [SHS.GEO]Humanities and Social Sciences/Geography, [SPI.OTHER]Engineering Sciences [physics]/Other |
| الوصف: | International audience ; These authors contributed equally to this work. Abstract. In areas of seasonal malaria transmission, the incidence rate of malaria infection is presumed to be near zero at the end of the dry season. Asymptomatic individuals may constitute a major parasite reservoir during this time. We conducted a longitudinal analysis of the spatio-temporal distribution of clinical malaria and asymptomatic parasitemia over time in a Malian town to highlight these malaria transmission dynamics. For a cohort of 300 rural children followed over 2009–2014, periodicity and phase shift between malaria and rainfall were determined by spectral analysis. Spatial risk clusters of clinical episodes or carriage were identified. A nested-case-control study was conducted to assess the parasite carriage factors. Malaria infection persisted over the entire year with seasonal peaks. High transmission periods began 2–3 months after the rains began. A cluster with a low risk of clinical malaria in the town center persisted in high and low transmission periods. Throughout 2009–2014, cluster locations did not vary from year to year. Asymptomatic and gametocyte carriage were persistent, even during low transmission periods. For high transmission periods, the ratio of asymptomatic to clinical cases was approximately 0.5, but was five times higher during low transmission periods. Clinical episodes at previous high transmission periods were a protective factor for asymptomatic carriage, but carrying parasites without symptoms at a previous high transmission period was a risk factor for asymptomatic carriage. Stable malaria transmission was associated with sustained asymptomatic carriage during dry seasons. Control strategies should target persistent low-level parasitemia clusters to interrupt transmission. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | ird-01630569; https://ird.hal.science/ird-01630569Test; https://ird.hal.science/ird-01630569/documentTest; https://ird.hal.science/ird-01630569/file/tpmd170074-COULIBALY_2017.pdfTest; IRD: fdi:010072015 |
| DOI: | 10.4269/ajtmh.17-0074 |
| الإتاحة: | https://doi.org/10.4269/ajtmh.17-0074Test https://ird.hal.science/ird-01630569Test https://ird.hal.science/ird-01630569/documentTest https://ird.hal.science/ird-01630569/file/tpmd170074-COULIBALY_2017.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.1317B42C |
| قاعدة البيانات: | BASE |
| DOI: | 10.4269/ajtmh.17-0074 |
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