التفاصيل البيبلوغرافية
| العنوان: |
Galectin-3, Inflammation, and the Risk of Atrial High-Rate Episodes in Patients with Dual Chamber Pacemakers |
| المؤلفون: |
Gelu Radu Simu, Raluca Tomoaia, Radu Ovidiu Rosu, Gabriel Gusetu, Mihai Puiu, Gabriel Cismaru, Bogdan Caloian, Andreea Terec, Teodor Buliga, Armand Boer, Ioan Alexandru Minciuna, Gyorgy Bodizs, Dumitru Zdrenghea, Dana Pop |
| المصدر: |
International Journal of Molecular Sciences; Volume 24; Issue 9; Pages: 7710 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2023 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
atrial high-rate episodes, AHREs, galectin-3, inflammation |
| جغرافية الموضوع: |
agris |
| الوصف: |
Atrial high-rate episodes (AHREs) are atrial tachyarrhythmias that are exclusively detected by cardiac implantable electronic devices (CIEDs) with an atrial lead. The objective of this study was to investigate the incidence and predictive factors for AHREs, and to evaluate the ability of inflammation biomarkers to predict the occurrence of AHREs. 102 patients undergoing CIED procedure who received a dual chamber pacemaker were included. CIED interrogation was performed 1 year after the implantation procedure. Patients were divided into groups according to the occurrence of AHREs, which was the primary endpoint of the study. The mean age of the patients was of 73 ± 8.6 years and 48% were male. The incidence of AHREs was 67% at 1 year follow-up. Patients with AHREs were older, had higher left atrial indexed volume (LAVi), higher baseline galectin-3 levels (1007.5 ± 447.3 vs. 790 ± 411.7 pg/mL) and received betablockers more often, along with amiodarone and anticoagulants. Interestingly, the CHADSVASC score did not differ significantly between the two groups. A cut-off value of galectin > 990 pg/mL predicted AHREs with moderate accuracy (AUC of 0.63, 95% CI 0.52 to 0.73, p = 0.04), and this association was confirmed in the univariate regression analysis (OR 1.0012, 95% CI 1.0001 to 1.0023, p = 0.0328). However, based on the multivariate regression analysis, galectin lost its prognostic significance under the effect of LAVi, which remained the only independent predictor of AHREs (OR 1.0883, 95% CI 1.0351 to 1.1441, p = 0.0009). AHREs are common in CIEDs patients. Galectin-3 may bring additional data in the prediction of AHREs. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Molecular Pharmacology; https://dx.doi.org/10.3390/ijms24097710Test |
| DOI: |
10.3390/ijms24097710 |
| الإتاحة: |
https://doi.org/10.3390/ijms24097710Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.12E7857B |
| قاعدة البيانات: |
BASE |
