دورية أكاديمية
Identification of context-dependent expression quantitative trait loci in whole blood
| العنوان: | Identification of context-dependent expression quantitative trait loci in whole blood |
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| المؤلفون: | Pital-Zhernakova, Daria, Deelen, Patrick, Vermaat, Martijn, van Iterson, Maarten, van Galen, Michiel, Arindrarto, Wibowo, van 't Hof, Peter, Mei, Hailiang, van Dijk, Freerk, Westra, Harm-Jan, Bonder, Marc Jan, van Rooij, Jeroen, Verkerk, Marijn, Jhamai, P. Mila, Moed, Matthijs, Kielbasa, Szymon M., Bot, Jan, Nooren, Irene, Pool, Rene, van Dongen, Jenny, Hottenga, Jouke J., Stehouwer, Coen D. A., van der Kallen, Carla J. H., Schalkwijk, Casper G., Zhernakova, Alexandra, Li, Yang, Tigchelaar, Ettje F., de Klein, Niek, Beekman, Marian, Deelen, Joris, van Heemst, Diana, van den Berg, Leonard H., Hofman, Albert, Uitterlinden, Andre G., van Greevenbroek, Marleen M. J., Veldink, Jan H., Boomsma, Dorret I., van Duijn, Cornelia M., Wijmenga, Cisca, Slagboom, P. Eline, Swertz, Morris A., Isaacs, Aaron, van Meurs, Joyce B. J., Jansen, Rick, Heijmans, Bastiaan T., 't Hoen, Peter A. C., Franke, Lude |
| المصدر: | Pital-Zhernakova , D , Deelen , P , Vermaat , M , van Iterson , M , van Galen , M , Arindrarto , W , van 't Hof , P , Mei , H , van Dijk , F , Westra , H-J , Bonder , M J , van Rooij , J , Verkerk , M , Jhamai , P M , Moed , M , Kielbasa , S M , Bot , J , Nooren , I , Pool , R , van Dongen , J , Hottenga , J J , Stehouwer , C D .... |
| سنة النشر: | 2017 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | GENE-EXPRESSION, DISEASE ASSOCIATIONS, HUMAN NEUTROPHILS, CELL, GENOME, VARIANTS, OBESITY, ENRICHMENT, INFECTION, ALLELES |
| الوصف: | Genetic risk factors often localize to noncoding regions of the genome with unknown effects on disease etiology1,2. Expression quantitative trait loci (eQTLs) help to explain the regulatory mechanisms underlying these genetic associations(3-6). Knowledge of the context that determines the nature and strength of eQTLs may help identify cell types relevant to pathophysiology and the regulatory networks underlying disease(7-17). Here we generated peripheral blood RNA-seq data from 2,116 unrelated individuals and systematically identified context-dependent eQTLs using a hypothesis-free strategy that does not require previous knowledge of the identity of the modifiers. Of the 23,060 significant cis-regulated genes (false discovery rate (FDR) |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://research.rug.nl/en/publications/ed040068-a240-4d6b-ab73-5f72d12a002eTest |
| DOI: | 10.1038/ng.3737 |
| الإتاحة: | https://doi.org/10.1038/ng.3737Test https://hdl.handle.net/11370/ed040068-a240-4d6b-ab73-5f72d12a002eTest https://research.rug.nl/en/publications/ed040068-a240-4d6b-ab73-5f72d12a002eTest |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.12B32DDF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/ng.3737 |
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