دورية أكاديمية
Citrullination of α2-antiplasmin is unlikely to contribute to enhanced plasmin generation in COVID-19 pathophysiology
| العنوان: | Citrullination of α2-antiplasmin is unlikely to contribute to enhanced plasmin generation in COVID-19 pathophysiology |
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| المؤلفون: | Kangro K., Campbell R.A., Tilvawala R., Flick M.J., Wolberg A.S. |
| المصدر: | Research and Practice in Thrombosis and Haemostasis, 7(6) |
| بيانات النشر: | Elsevier B.V. |
| سنة النشر: | 2023 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| مصطلحات موضوعية: | myeloperoxidase, female, anticoagulation, immunoprecipitation, leukocyte activation, diabetes mellitus, activated partial thromboplastin time, inflammation, male, thrombosis, fibrinolysis, enzyme linked immunosorbent assay, plasminogen, adult, protein expression, Letter, plasmin, 2,3 butanedione, citrulline, densitometry, citrullination, controlled study, immunoblotting, fibrin formation, phenazone, pathophysiology, middle aged, coronavirus disease 2019, venous thromboembolism, neutrophil extracellular trap |
| الوصف: | COVID-19 is caused by the SARS-CoV-2. Severe COVID-19 is characterized by immune cell activation, leading to inflammation and the formation of neutrophil extracellular traps (NETs). COVID-19 is also associated with an imbalance in coagulation and fibrinolytic activity. Exuberant fibrinogen production secondary to the inflammatory response, coupled with elevated thrombin generation, provokes fibrin deposition. However, despite paradoxically increased plasmin generation potential in plasma from patients with COVID-19, fibrinolytic pathways are unable to counter this process. Patients with severe COVID-19 have a high risk of developing venous thromboembolism, and patients with COVID-19 with venous thromboembolism have an increased risk of death. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.17615/tffz-8f03Test; https://cdr.lib.unc.edu/downloads/wp988w92s?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/wp988w92sTest |
| DOI: | 10.17615/tffz-8f03 |
| الإتاحة: | https://doi.org/10.17615/tffz-8f03Test https://cdr.lib.unc.edu/downloads/wp988w92s?file=thumbnailTest https://cdr.lib.unc.edu/downloads/wp988w92sTest |
| رقم الانضمام: | edsbas.127B8A |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/tffz-8f03 |
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