مؤتمر
Age-, period- and cohort modelling of type 1 diabetes incidence in Europe among children age 0-15 years
| العنوان: | Age-, period- and cohort modelling of type 1 diabetes incidence in Europe among children age 0-15 years |
|---|---|
| المؤلفون: | Ibfelt, EH, Carstensen, B, Patterson, C, Dahlquist, G, Neu, A, Rosenbauer, J, Skrivarhaug, T, Bratina, N, Rami-Merhar, B, Jarosz-Chobot, P, Cinek, O, Marčiulionytė, Dalė, Ionescu-Tirgoviste, C, deBeaufort, C, McNally, R, Gillespie, K, Gorus, F, Castell, C, Konrad, D, Kocov, M, Svensson, J |
| المصدر: | Pediatric Diabetes: Abstracts for the 45th Annual Meeting of the International Society for Pediatric and Adolescent Diabetes (ISPAD 2019) : October 30-November 2, 2019, Boston, USA, Copenhagen : Wiley Blackwell ; Munksgaard, 2019, vol. 20, iss. suppl. 28, p. 94-94, no. P111 ; ISSN 1399-543X |
| سنة النشر: | 2019 |
| المجموعة: | LAEI VL (Lithuanian Institute of Agrarian Economics Virtual Library) / LAEI VB (Lietuvos agrarinės ekonomikos institutasvirtualią biblioteką) |
| مصطلحات موضوعية: | diabetes Epidemiology, Genetics, Immunology, Environment |
| الوصف: | Aim: Describe incidence trends in type 1 diabetes (T1D) for centers participating in EURODIAB 1989 to 2013 using fine modelling age-period and cohort models (APC-models). Methods: Each center delivered data in one-year age classes of type 1 Diabetes cases age 0-15 years. Cases were validated using capture-recapture methods. There were 57,725 individual cases from 19 centres from 16 countries. We used age-period-cohort models with natural splines for the age, period and cohort effects, and calculated the overall drift for each country. Further a likelihood ratio test was used to test for non-linearity of period and cohort effects. We fitted a final age-cohort model for all centres with separate age-effect for boys and girls and separate cohort effect for each center. Results: There was no clear common cohort effect across centers, and the non-linear period-effects were small. The overall result was an increase in incidence with the highest increase observed in countries with the lowest incidence. During the entire period 1989-2013 Sweden had the highest incidence and Macedonia had the lowest incidence. The male:female ratio changed with age, with a higher rate in boys in the youngest (< 5 years of age) and in the oldest (> 12 years of age). The peak incidence was at age 12 years for girls and at age 13 years for boys (see attached figure). Conclusion: The modelling in 1-year classes allowed us to show the changing male:female ratio with age. A common cohort effect across Europe could not be confirmed, but we found that centres with the lowest incidence rates had the largest increase over time. [.]. |
| نوع الوثيقة: | conference object |
| اللغة: | English |
| العلاقة: | http://lsmu.lvb.lt/LSMU:ELABAPDB81378632&prefLang=en_USTest |
| الإتاحة: | https://doi.org/10.1111/pedi.12926Test http://lsmu.lvb.lt/LSMU:ELABAPDB81378632&prefLang=en_USTest |
| رقم الانضمام: | edsbas.126F4768 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |