دورية أكاديمية
Adiposity Is Related to Inflammatory Disease Activity in Juvenile Idiopathic Arthritis
| العنوان: | Adiposity Is Related to Inflammatory Disease Activity in Juvenile Idiopathic Arthritis |
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| المؤلفون: | Diaz-Cordovés Rego, Gisela, Núñez-Cuadros, Esmeralda, Mena-Vázquez, Natalia, Aguado Henche, Soledad, Galindo-Zavala, Rocío, Manrique-Arija, Sara, Martín-Pedraz, Laura, Redondo-Rodríguez, Rocio, Godoy-Navarrete, Francisco Javier, Fernández-Nebro, Antonio |
| المساهمون: | Diaz-Cordovés Rego,G, Mena-Vázquez,N, Manrique-Arija,S, Redondo-Rodríguez,R, Godoy-Navarrete,FJ, Fernández-Nebro,A Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain. Diaz-Cordovés Rego,G, Fernández-Nebro,A UGC de Reumatología, Hospital Regional Universitario de Málaga, Málaga, Spain. Núñez-Cuadros,E, Galindo-Zavala,R, Martín-Pedraz,L UGC de Pediatría, Hospital Regional Universitario de Málaga, Málaga, Spain. Aguado Henche,S Departamento de Anatomía y Embriología Humana, Facultad de Medicina, Universidad de Alcalá de Henares, Madrid, Spain. Fernández-Nebro,A Departamento de Medicina, Universidad de Málaga, Málaga, Spain., This research was funded by a grant for medical researchers of the “Sociedad Española de Reumatología Pediatrica” |
| بيانات النشر: | MDPI |
| سنة النشر: | 2021 |
| المجموعة: | Sistema Sanitario Público de Andalucía (SSPA): Repositorio |
| مصطلحات موضوعية: | Juvenile idiopathic arthritis, Adiposity, Inflammatory disease activity, Body mass index, Dual-energy x-ray absorptiometry, Overweight, Obesity, Body composition, Artritis juvenil, Adiposidad, Índice de masa corporal, Absorciometría de fotón, Sobrepeso, Obesidad, Composición corporal, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Mass Index, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Radiography::Absorptiometry, Photon, Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weight::Overweight, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Fat Distribution::Adiposity, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies, Medical Subject Headings::Diseases::Musculoskeletal Diseases::Joint Diseases::Arthritis::Arthritis, Juvenile, Medical Subject Headings::Anatomy::Body Regions::Extremities::Lower Extremity::Leg, Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Body Composition, Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity, Medical Subject Headings::Anatomy::Tissues::Connective Tissue::Adipose Tissue |
| الوصف: | Objective: To identify factors associated with the higher proportion of fatty tissue and overweight/obesity observed in patients with juvenile idiopathic arthritis (JIA). Patients and methods: We performed a cross-sectional study of 80 JIA patients aged 4–15 years with 80 age- and sex-matched healthy controls. Body composition was assessed using dual-energy x-ray absorptiometry. The 27-joint Juvenile Arthritis Disease Activity score (JADAS27) was calculated. Two multivariate models were constructed to identify factors associated with overweight/obesity and fat mass index (FMI). Results: No differences were found between cases and controls in body mass index (BMI) or body composition. However, compared with controls, patients with a high inflammatory activity (JADAS27 > 4.2 for oligoarticular JIA or >8.5 for polyarticular disease) had higher values for BMI (p = 0.006); total fat mass (p = 0.003); FMI (p = 0.001); and fat in the legs (p = 0.001), trunk (p = 0.001), and arms (p = 0.002). The factors associated with overweight/obesity in patients were the duration of therapy with biological drugs, measured in months (OR [95% CI] = 1.12 [1.02–1.04]; p = 0.037), and physical activity (OR [95% CI] = 0.214 [0.07–0.68]; p = 0.010), while the factors associated with FMI were age (β [95% CI] = 0.30 [0.17–1.41]; p = 0.014), JADAS27 (β [95% CI] = 0.45 [0.16–1.08]; p = 0.009), and physical activity (β [95% CI] = −0.22 [−5.76 to 0.29]; p = 0.031). Conclusion: Our study revealed no differences between JIA patients with well-controlled disease and low disability and the healthy population in BMI or body composition. Furthermore, the association observed between inflammatory activity and adiposity could be responsible for poorer clinical course. ; Yes |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2077-0383 |
| العلاقة: | https://www.mdpi.com/2077-0383/10/17/3949/htmTest; Diaz-Cordovés Rego G, Núñez-Cuadros E, Mena-Vázquez N, Aguado Henche S, Galindo-Zavala R, Manrique-Arija S, et al. Adiposity Is Related to Inflammatory Disease Activity in Juvenile Idiopathic Arthritis. J Clin Med. 2021 Aug 31;10(17):3949; http://hdl.handle.net/10668/4274Test; PMC8432058 |
| DOI: | 10.3390/jcm10173949 |
| الإتاحة: | https://doi.org/10.3390/jcm10173949Test http://hdl.handle.net/10668/4274Test |
| حقوق: | Atribución 4.0 Internacional ; http://creativecommons.org/licenses/by/4.0Test/ ; open access |
| رقم الانضمام: | edsbas.10B5A120 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20770383 |
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| DOI: | 10.3390/jcm10173949 |