دورية أكاديمية
Identification of the tumour transition states occurring during EMT.
| العنوان: | Identification of the tumour transition states occurring during EMT. |
|---|---|
| المؤلفون: | Pastushenko, Ievgenia, Brisebarre, Audrey, Sifrim, Alejandro, Fioramonti, Marco, Revenco, Tatiana, Boumahdi, Soufiane, Van Keymeulen, Alexandra, Brown, Daniel, Moers, Virginie, Lemaire, Sophie, De Clercq, Sarah, Minguijon Perez, Esmeralda, Balsat, Cédric, Sokolow, Youri, Dubois, Christine, De Cock, Florian, Scozzaro, Samuel, Sopena, Federico, Lanas, Angel, D'Haene, Nicky, Salmon, Isabelle, Marine, Jean-Christophe, Voet, Thierry, Sotiropoulou, Panagiota A, Blanpain, Cédric |
| المصدر: | Nature (London), 556 (7702 |
| سنة النشر: | 2018 |
| المجموعة: | DI-fusion : dépôt institutionnel de l'Université libre de Bruxelles (ULB) |
| مصطلحات موضوعية: | Sciences bio-médicales et agricoles, Animals, Chromatin -- genetics, Epigenesis, Genetic, Epithelial Cells -- metabolism -- pathology, Epithelial-Mesenchymal Transition -- genetics, Female, Gene Expression Regulation, Neoplastic, Gene Regulatory Networks, Humans, Male, Mammary Neoplasms, Animal -- genetics -- pathology, Mesoderm -- metabolism -- pathology, Mice, Neoplasm Invasiveness -- genetics -- pathology, Neoplasm Metastasis -- genetics -- pathology, Neoplasms -- genetics -- pathology, Signal Transduction, Skin Neoplasms -- genetics -- pathology, Transcription |
| الوصف: | In cancer, the epithelial-to-mesenchymal transition (EMT) is associated with tumour stemness, metastasis and resistance to therapy. It has recently been proposed that, rather than being a binary process, EMT occurs through distinct intermediate states. However, there is no direct in vivo evidence for this idea. Here we screen a large panel of cell surface markers in skin and mammary primary tumours, and identify the existence of multiple tumour subpopulations associated with different EMT stages: from epithelial to completely mesenchymal states, passing through intermediate hybrid states. Although all EMT subpopulations presented similar tumour-propagating cell capacity, they displayed differences in cellular plasticity, invasiveness and metastatic potential. Their transcriptional and epigenetic landscapes identify the underlying gene regulatory networks, transcription factors and signalling pathways that control these different EMT transition states. Finally, these tumour subpopulations are localized in different niches that differentially regulate EMT transition states. ; SCOPUS: ar.j ; info:eu-repo/semantics/published |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 1 full-text file(s): application/pdf |
| اللغة: | English |
| العلاقة: | uri/info:doi/10.1038/s41586-018-0040-3; uri/info:pii/10.1038/s41586-018-0040-3; uri/info:pmid/29670281; uri/info:scp/85048322025; https://dipot.ulb.ac.be/dspace/bitstream/2013/271836/4/s41586-018-0040-3.pdfTest; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/271836Test |
| الإتاحة: | http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/271836Test https://dipot.ulb.ac.be/dspace/bitstream/2013/271836/4/s41586-018-0040-3.pdfTest |
| رقم الانضمام: | edsbas.10A0B70A |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |