دورية أكاديمية
Autoimmune hepatitis in a demographically isolated area of Australia
| العنوان: | Autoimmune hepatitis in a demographically isolated area of Australia |
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| المؤلفون: | Haider, Ali, Kaye, G., Thomson, Andrew |
| المصدر: | Internal Medicine Journal |
| بيانات النشر: | Blackwell Science Asia |
| المجموعة: | Australian National University: ANU Digital Collections |
| مصطلحات موضوعية: | Keywords: azathioprine, mercaptopurine, serum globulin, steroid, adult, article, Australia, autoimmune hepatitis, clinical article, drug withdrawal, female, human, liver cirrhosis, liver failure, low drug dose, male, priority journal, remission, sex ratio, treatmen Autoimmune disease, Autoimmune hepatitis type 1, Liver disease |
| الوصف: | Background: Previous studies describing autoimmune hepatitis (AIH) come from liver transplant centres in which a skewed distribution of cases may give a misleading picture of the incidence of AIH and its natural history. This series describes AIH in a stable and demographically discrete population of patients in the Australian Capital Territory (ACT) and the surrounding region. Methods: In 42 patients with type 1 AIH (point prevalence 8 per 100 000 population), clinical, laboratory and histological features at presentation, response to initial therapy, details of maintenance therapy and outcome were recorded. Results: Consistent with other publications, the male-to-female ratio was 1:3, mean age at presentation was 53 years and 24% had cirrhosis at diagnosis. Most patients (86%) responded to initial therapy and 67% went into long-term remission. One patient died from liver failure and none required liver transplantation. Azathioprine was included in the treatment regimen in 74% of cases with doses generally <2 mg/kg. Azathioprine dose greater than or equal to 2 mg/kg was associated with better clinical outcome, but this did not reach statistical significance. A higher proportion of female patients had cirrhosis at presentation (9/10 vs 1/10; P = 0.24). Conclusion: In this Australian community-based study, type 1 AIH was primarily a disease of later life, responded to conventional immunosuppressive therapy and generally has a good prognosis. Further study of the use of azathioprine is warranted to determine the optimal dose. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 1444-0903 |
| العلاقة: | http://hdl.handle.net/1885/62209Test; https://openresearch-repository.anu.edu.au/bitstream/1885/62209/7/01_Haider_Autoimmune_hepatitis_in_a_2010.pdf.jpgTest |
| DOI: | 10.1111/j.1445-5994.2009.02041.x |
| الإتاحة: | https://doi.org/10.1111/j.1445-5994.2009.02041.xTest http://hdl.handle.net/1885/62209Test https://openresearch-repository.anu.edu.au/bitstream/1885/62209/7/01_Haider_Autoimmune_hepatitis_in_a_2010.pdf.jpgTest |
| رقم الانضمام: | edsbas.1054ED5A |
| قاعدة البيانات: | BASE |
| تدمد: | 14440903 |
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| DOI: | 10.1111/j.1445-5994.2009.02041.x |