دورية أكاديمية
One-year outcome of critically ill patients with systemic rheumatic disease: a multicenter cohort study
| العنوان: | One-year outcome of critically ill patients with systemic rheumatic disease: a multicenter cohort study |
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| المؤلفون: | Larcher, R., Pineton de Chambrun, Marc, Garnier, Fanny, Rubenstein, Emma, Carr, Julie, Charbit, Jonathan, Chalard, Kevin, Mourad, Marc, Amalric, Matthieu, Platon, Laura, Brunot, Vincent, Amoura, Zahir, Jaber, Samir, Jung, Boris, Luyt, Charles-Edouard, Klouche, Kada |
| المساهمون: | Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut de cardiologie CHU Pitié-Salpêtrière, CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition CHU Pitié Salpêtrière (IHU ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière AP-HP |
| المصدر: | ISSN: 0012-3692. |
| بيانات النشر: | HAL CCSD American College of Chest Physicians |
| سنة النشر: | 2020 |
| المجموعة: | Université de Montpellier: HAL |
| مصطلحات موضوعية: | corticosteroids, intensive care, outcomes, prognostic factors, systemic rheumatic diseases, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Background: Critically ill patients with systemic rheumatic disease (SRD) have benefited from better provision of rheumatic and critical care in recent years. Recent comprehensive data regarding in-hospital mortality rates and, most importantly, long-term outcomes are scarce.Research question: The aim of this study was to assess short and long-term outcome of patients with SRD who were admitted to the ICU.Study design and methods: All records of patients with SRD who were admitted to ICU between 2006 and 2016 were reviewed. In-hospital and one-year mortality rates were assessed, and predictive factors of death were identified.Results: A total of 525 patients with SRD were included. Causes of admission were most frequently shock (40.8%) and acute respiratory failure (31.8%). Main diagnoses were infection (39%) and SRD flare-up (35%). In-hospital and one-year mortality rates were 30.5% and 37.7%, respectively. Predictive factors that were associated with in-hospital and one-year mortalities were, respectively, age, prior corticosteroid therapy, simplified acute physiology score II ≥50, need for invasive mechanical ventilation, or need for renal replacement therapy. Knaus scale C or D and prior conventional disease modifying antirheumatic drug therapy was associated independently with death one-year after ICU admission.Interpretation: Critically ill patients with SRD had a fair outcome after an ICU stay. Increased age, prior corticosteroid therapy, and severity of critical illness were associated significantly with short- and long-term mortality rates. The one-year mortality rate was also associated with prior health status and conventional disease modifying antirheumatic drug therapy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/32289313; hal-02543275; https://hal.science/hal-02543275Test; https://hal.science/hal-02543275/documentTest; https://hal.science/hal-02543275/file/2020%20Larcher%20et%20al.,%20One%20year.pdfTest; PUBMED: 32289313 |
| DOI: | 10.1016/j.chest.2020.03.050 |
| الإتاحة: | https://doi.org/10.1016/j.chest.2020.03.050Test https://hal.science/hal-02543275Test https://hal.science/hal-02543275/documentTest https://hal.science/hal-02543275/file/2020%20Larcher%20et%20al.,%20One%20year.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.103B85DA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.chest.2020.03.050 |
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