دورية أكاديمية
Independent association of estimated pulse-wave velocity with all-cause mortality in individuals with type 2 diabetes
| العنوان: | Independent association of estimated pulse-wave velocity with all-cause mortality in individuals with type 2 diabetes |
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| المؤلفون: | Solini, Anna, Orsi, Emanuela, Vitale, Martina, Garofolo, Monia, Resi, Veronica, Bonora, Enzo, Fondelli, Cecilia, Trevisan, Roberto, Vedovato, Monica, Nicolucci, Antonio, Penno, Giuseppe, Pugliese, Giuseppe |
| المساهمون: | Solini, Anna, Orsi, Emanuela, Vitale, Martina, Garofolo, Monia, Resi, Veronica, Bonora, Enzo, Fondelli, Cecilia, Trevisan, Roberto, Vedovato, Monica, Nicolucci, Antonio, Penno, Giuseppe, Pugliese, Giuseppe |
| بيانات النشر: | GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND OXFORD UNIV PRESS |
| سنة النشر: | 2024 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | arterial stiffne, estimated pulse wave velocity, all-cause mortality |
| الوصف: | Background Estimated pulse-wave velocity (ePWV), a surrogate measure of arterial stiffness, was shown to independently predict morbidity and mortality from cardiovascular disease and other causes in both the general population and high-risk individuals. However, in people with type 2 diabetes, it is unknown whether ePWV adds prognostic information beyond the parameters used for calculating it.Aims To assess the independent association of ePWV with all-cause mortality in individuals with type 2 diabetes.Design Prospective cohort study that enrolled 15 773 patients in 19 Italian centres in 2006-08.Methods ePWV was calculated from a regression equation using age and mean blood pressure (BP). All-cause mortality was retrieved for 15 656 patients in 2015.Results Percentage and rate of deaths, Kaplan-Meier estimates and unadjusted hazard ratios increased from Quartile I to Quartile IV of ePWV. After adjustment for age, sex, BP levels and anti-hypertensive treatment, the strength of association decreased but mortality risk remained significantly higher for Quartiles II (+34%), III (+82%) and IV (+181%) vs. Quartile I and was virtually unchanged when further adjusting for other cardiovascular risk factors and complications/comorbidities. Each m center dot s- 1 increase in ePWV was associated with an increased adjusted risk of death in the whole cohort (+53%) and in participants with (+52%) and without (+65%) cardiorenal complications. Moreover, ePWV significantly improved prediction of mortality risk over cardiovascular risk factors and complications/comorbidities, though the net increase was modest.Conclusions These findings suggest that ePWV may represent a simple and inexpensive tool for providing prognostic information beyond traditional cardiovascular risk factors.Trial registration ClinicalTrials.gov, NCT00715481, https://clinicaltrials.gov/ct2/show/NCT00715481Test. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/38200621; info:eu-repo/semantics/altIdentifier/wos/WOS:001150424200001; journal:QJM-AN INTERNATIONAL JOURNAL OF MEDICINE; https://hdl.handle.net/11573/1706206Test |
| DOI: | 10.1093/qjmed/hcae012 |
| الإتاحة: | https://doi.org/10.1093/qjmed/hcae012Test https://hdl.handle.net/11573/1706206Test |
| رقم الانضمام: | edsbas.1005DD1F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/qjmed/hcae012 |
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