We report the first observation of off-axis neutrino interactions in the MiniBooNE detector from the NuMI beamline at Fermilab. The MiniBooNE detector is located 745 m from the NuMI production target, at 110 mrad angle ($6.3^{\circ}$) with respect to the NuMI beam axis. Samples of charged current quasi-elastic $\nu_{\mu}$ and $\nu_e$ interactions are analyzed and found to be in agreement with expectation. This provides a direct verification of the expected pion and kaon contributions to the neutrino flux and validates the modeling of the NuMI off-axis beam. Comment: 4 pages, 5 figures, Submitted to Phys. Rev. Lett