Magnetic resonance imaging does not reveal structural alterations in the brain of grapheme-color synesthetes
| العنوان: | Magnetic resonance imaging does not reveal structural alterations in the brain of grapheme-color synesthetes |
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| المؤلفون: | Dojat, Michel, Pizzagalli, Fabrizio, Hupé, Jean-Michel |
| المساهمون: | Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Keck School of Medicine [Los Angeles], University of Southern California (USC), Centre de recherche cerveau et cognition (CERCO), Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | PLoS ONE PLoS ONE, Public Library of Science, 2018, 13 (4), pp.e0194422. ⟨10.1371/journal.pone.0194422⟩ PLoS ONE, Vol 13, Iss 4, p e0194422 (2018) |
| بيانات النشر: | Public Library of Science, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Central Nervous System, Adult, Male, Imaging Techniques, Permutation, Brain Morphometry, lcsh:Medicine, Social Sciences, Datasets as Topic, Neuroimaging, Research and Analysis Methods, Nervous System, Diagnostic Radiology, Perceptual Disorders, Diagnostic Medicine, Medicine and Health Sciences, Psychology, Humans, lcsh:Science, Brain Mapping, Discrete Mathematics, [SCCO.NEUR]Cognitive science/Neuroscience, Radiology and Imaging, Morphometry, lcsh:R, Biology and Life Sciences, Brain, Magnetic Resonance Imaging, Diffusion Tensor Imaging, Pattern Recognition, Visual, Combinatorics, Physical Sciences, lcsh:Q, Sensory Perception, Female, Anatomy, Voxel-Based Morphometry, Synesthesia, Mathematics, Color Perception, Photic Stimulation, Research Article, Neuroscience |
| الوصف: | Several publications have reported structural changes in the brain of synesthetes compared to controls, either local differences or differences in connectivity. In the present study, we pursued this quest for structural brain differences that might support the subjective experience of synesthesia. In particular, for the first time in this field, we investigated brain folding in comparing 45 sulcal shapes in each hemisphere of control and grapheme-color synesthete populations. To overcome flaws relative to data interpretation based only on p-values, common in the synesthesia literature, we report confidence intervals of effect sizes. Moreover, our statistical maps are displayed without introducing the classical, but misleading, p-value level threshold. We adopt such a methodological procedure to facilitate appropriate data interpretation and promote the "New Statistics" approach. Based on structural or diffusion magnetic resonance imaging data, we did not find any strong cerebral anomaly, in sulci, tissue volume, tissue density or fiber organization that could support synesthetic color experience. Finally, by sharing our complete datasets, we strongly support the multi-center construction of a sufficient large dataset repository for detecting, if any, subtle brain differences that may help understanding how a subjective experience, such as synesthesia, is mentally constructed. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f7d966381899f5e5dec6921acd682001Test http://europepmc.org/articles/PMC5884511Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....f7d966381899f5e5dec6921acd682001 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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