Better HbA1c during the first years after diagnosis of type 1 diabetes is associated with residual C peptide 10 years later
| العنوان: | Better HbA1c during the first years after diagnosis of type 1 diabetes is associated with residual C peptide 10 years later |
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| المؤلفون: | Grönberg, Annika, Espes, Daniel, Carlsson, Per-Ola |
| المصدر: | BMJ Open Diabetes Research & Care, Vol 8, Iss 1 (2020) BMJ Open Diabetes Research & Care |
| بيانات النشر: | BMJ Publishing Group, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, sex differences, HbA1c, Adolescent, Enzyme-Linked Immunosorbent Assay, Endocrinology and Diabetes, Clinical Care/Education/Nutrition, Diseases of the endocrine glands. Clinical endocrinology, Body Mass Index, Young Adult, Sex Factors, Humans, Longitudinal Studies, Registries, Child, Glycated Hemoglobin, Sweden, C-Peptide, Infant, RC648-665, Diabetes Mellitus, Type 1, type 1, Child, Preschool, Endokrinologi och diabetes, glycemic control, Female, C-peptide, celiac disease, Follow-Up Studies |
| الوصف: | Objective: To identify the factors associated with residual C peptide production at least 10 years after diagnosis in children and adolescents with type 1 diabetes. Research design and methods: 73 children and adolescents (= 1.17pmol/L). The average hemoglobin A1c (HbA1c) was calculated during each of the 10 years after diagnosis and further grand average was calculated for the entire study period. Results: C peptide was detectable in 38% of participants. The C peptide concentration was 4.35.3pmol/L. At onset of type 1 diabetes, participants were on average approximately 5years of age, and their average HbA1c was 9.4% (79mmol/mol). During the first 3years after diagnosis, HbA1c was lower in the group with detectable C peptide at follow-up >= 10 years later. Moreover, detectable C peptide was more common among female participants. Body mass index SD scores had not increased since the 1-year follow-up, but were higher in patients with measurable C peptide. Nine participants (12%) had been diagnosed with celiac disease and two (3%) with hypothyreosis. Eighteen (25%) participants had retinopathy. Conclusions: Children and adolescents with detectable C peptide after more than 10 years of diabetes duration were predominantly female and had better HbA1c than others during the first 3years after diagnosis. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2052-4897 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::cf4cac83c70998b22be5321a999575ebTest https://drc.bmj.com/content/8/1/e000819.fullTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....cf4cac83c70998b22be5321a999575eb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20524897 |
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