Predicting cognitive resilience from midlife lifestyle and multi-modal MRI: A 30-year prospective cohort study
| العنوان: | Predicting cognitive resilience from midlife lifestyle and multi-modal MRI: A 30-year prospective cohort study |
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| المؤلفون: | Topiwala, A, Suri, S, Allan, C, Valkanova, V, Filippini, N, Sexton, C, Heise, V, Zsoldos, E, Mahmood, A, Singh-Manoux, A, Mackay, C, Kivimäki, M, Ebmeier, K |
| المصدر: | PLoS ONE, Vol 14, Iss 2, p e0211273 (2019) PLoS ONE PLOS ONE |
| بيانات النشر: | Public Library of Science, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Central Nervous System, Computer and Information Sciences, Imaging Techniques, Cognitive Neuroscience, Science, Social Sciences, Neuroimaging, Pathology and Laboratory Medicine, Research and Analysis Methods, Alzheimer's Disease, Network Resilience, Nervous System, Diagnostic Radiology, Signs and Symptoms, Sociology, Diagnostic Medicine, Mental Health and Psychiatry, Medicine and Health Sciences, Humans, Cognitive Dysfunction, Social Stratification, Prospective Studies, Life Style, Aged, Cognitive Impairment, Brain Mapping, Cognitive Neurology, Radiology and Imaging, Brain, Biology and Life Sciences, Neurodegenerative Diseases, Middle Aged, Magnetic Resonance Imaging, Neurology, Cognitive Science, Medicine, Female, Dementia, Atrophy, Anatomy, Network Analysis, Research Article, Neuroscience |
| الوصف: | Background There is significant heterogeneity in the clinical expression of structural brain abnormalities, including Alzheimer’s disease biomarkers. Some individuals preserve their memory despite the presence of risk factors or pathological brain changes, indicating resilience. We aimed to test whether resilient individuals could be distinguished from those who develop cognitive impairment, using sociodemographic variables and neuroimaging. Methods We included 550 older adults participating in the Whitehall II study with longitudinal data, cognitive test results, and multi-modal MRI. Hippocampal atrophy was defined as Scheltens Scores >0. Resilient individuals (n = 184) were defined by high cognitive performance despite hippocampal atrophy (HA). Non-resilient participants (n = 133) were defined by low cognitive performance (≥1.5 standard deviations (S.D.) below the group mean) in the presence of HA. Dynamic and static exposures were evaluated for their ability to predict later resilience status using multivariable logistic regression. In a brain-wide analysis we tested for group differences in the integrity of white matter (structural connectivity) and resting-state networks (functional connectivity). Findings Younger age (OR: 0.87, 95% CI: 0.83 to 0.92, pConclusions Resilient individuals could be distinguished from those who developed impairments on the basis of sociodemographic characteristics, brain structural and functional connectivity, but not midlife lifestyles. There was a synergistic deleterious effect of hippocampal atrophy and poor white matter integrity on cognitive performance. Exploiting and supporting neural correlates of resilience could offer a fresh approach to postpone or avoid the appearance of clinical symptoms. |
| وصف الملف: | application/pdf |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c77bf61ab52744939686067d42517293Test https://doi.org/10.1371/journal.pone.0211273Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....c77bf61ab52744939686067d42517293 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |