Drug survival of the first course of anti-TNF agents in patients with rheumatoid arthritis and seronegative spondyloarthritis: Analysis from the monitornet databas
| العنوان: | Drug survival of the first course of anti-TNF agents in patients with rheumatoid arthritis and seronegative spondyloarthritis: Analysis from the monitornet databas |
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| المؤلفون: | Scirè, Ca, Caporali, R, Sarzi Puttini, P, Frediani, B, Di Franco, M, Tincani, A, Sinigaglia, L, Sfriso, P, Tirri, R, Bellis, E, Delsante, G, Porru, G, Salaffi, F, Giuggioli, D, Rossini, M, Todoerti, M, Bazzichi, L, Govoni, M, Gerli, R, Raschetti, R, Minisola, G, Montecucco, C, Todesco, S, Naldi, L, Galeazzi, M, Fantini, F, Mathieu, A, Valesini, G, Ferri, Clodoveo, Bambara, Lm, Grassi, W, Trotta, F, Adami, S, Lapadula, G, Pellerito, R, De Vita, S, Foti, R, Paolazzi, G, Bagnato, G, Cutolo, M, Rocchetta, Pa, Ferraccioli, G, Canesi, Ba, Matucci Cerinic, M, Vittorio, M, Canzoni, M. |
| المساهمون: | Scire', C, Caporali, R, Sarzi Puttini, P, Frediani, B, Di Franco, M, Tincani, A, Sinigaglia, L, Sfriso, P, Tirri, R, Bellis, E, Delsante, G, Porru, G, Salaffi, F, Giuggioli, D, Rossini, M, Todoerti, M, Bazzichi, L, Govoni, M, Gerli, R, Raschetti, R, Minisola, G, Montecucco, C, Todesco, S, Scirè, Ca, SARZI PUTTINI, P, DI FRANCO, M, Tirri, Rosella, Todesco, S. |
| المصدر: | Scopus-Elsevier Europe PubMed Central Università degli Studi di Padova-IRIS Publons |
| مصطلحات موضوعية: | rheumatoid arthritis, Adult, Male, Settore MED/16 - REUMATOLOGIA, Time Factors, Databases, Factual, databases, retention rate, Anti-TNFalpha blockers, Kaplan-Meier Estimate, Drug Administration Schedule, NO, anti-TNF, Rheumatoid arthritis, seronegative spondyloarthritis, Arthritis, Rheumatoid, Databases, anti-TNF therapies, Risk Factors, Rheumatoid, Spondylarthritis, Humans, Registries, Treatment Failure, Rheumatoid arthriti, Factual, Aged, Proportional Hazards Models, therapy, Tumor Necrosis Factor-alpha, Arthritis, seronegative spondyloarthriti, Middle Aged, Italy, Antirheumatic Agents, Multivariate Analysis, Female, Biomarkers |
| الوصف: | Objective: To compare drug survival of different anti-TNF drugs (inliximab, INF, etanercept, ETA, and adalimumab, ADA) in rheumatoid arthritis (RA) and spondyloarthritis (SpA) by analysing data collected from an Italian multicentre observational cohort study.Methods: All patients with RA or SpA registered in the MonitorNet database who started their irst course of anti-TNF therapy were included.Overall drug survival was measured, along with speciic reasons of discontinuation (ineficacy or adverse events).A first set of analyses using RA as reference category assessed the relationship between diagnosis and drug survival.A second set of analyses stratiied by diagnosis (RA and SpA) used INF as reference drug.Adjustment for confounders was performed.The results are presented as adjusted hazard ratios (adjHR) and 95% conidence intervals (95%CI).Results: 2640 RA patients and 1220 SpA patients with a median follow-up of 17 months (IQR 7.2-33.4) were included in the analyses.Patients with a diagnosis of SpA showed a lower risk of drug discontinuation with an adjHR (95%CI) of 0.81 (0.73, 0.90).In SpA, the subset of patients with ankylosing spondylitis (AS) showed the best survival on treatment.In RA, both ETA and ADA showed a signiicantly lower probability of withdrawal when compared to INF [adjHR (95%CI) 0.46 (0.38, 0.56) and 0.68 (0.57, 0.81), respectively].Similar results were found in SpA.Conclusion: Drug survival for SpA is longer than that in RA mainly due to the AS subgroup.In both RA and SpA, ETA and ADA showed a better retention on treatment when compared to INF. |
| وصف الملف: | STAMPA |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c2054afeb40d123a5b6fa9661c7a14f9Test http://www.scopus.com/inward/record.url?eid=2-s2.0-84892460666&partnerID=MN8TOARSTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....c2054afeb40d123a5b6fa9661c7a14f9 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |