Association of Long-Term Diet Quality with Hippocampal Volume : Longitudinal Cohort Study
| العنوان: | Association of Long-Term Diet Quality with Hippocampal Volume : Longitudinal Cohort Study |
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| المؤلفون: | Akbaraly, T, Sexton, C, Zsoldos, E, Mahmood, A, Filippini, N, Kerleau, C, Michel Verdier, J, Virtanen, M, Gabelle, A, Ebmeier, K, Kivimaki, M |
| المساهمون: | Department of Epidemiology and Public Health, Imperial College London, Mécanismes moléculaires dans les démences neurodégénératives (MMDN), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Department of Psychiatry, University of Oxford [Oxford], Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), Uppsala University, Département de neurologie [Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier]-Université de Montpellier (UM), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), University College of London [London] (UCL), Department of Public Health, Clinicum |
| المصدر: | The American Journal of Medicine The American Journal of Medicine, Elsevier [Commercial Publisher] 2018, 131 (11), pp.1372-1381.e4. ⟨10.1016/j.amjmed.2018.07.001⟩ |
| بيانات النشر: | Uppsala universitet, Folkhälsovetenskap, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, HIGH-FAT DIET, Alternative Healthy Eating Index, Hippocampus, Article, Cohort Studies, Humans, Cognitive Dysfunction, Longitudinal Studies, Prospective Studies, BRAIN, Prospective study, Exercise, METAANALYSIS, ComputingMilieux_MISCELLANEOUS, Aged, Dietary indices, Nutrition and Dietetics, MORTALITY, Public Health, Global Health, Social Medicine and Epidemiology, Feeding Behavior, WHITEHALL II COHORT, Middle Aged, COGNITIVE IMPAIRMENT, DEPRESSION, Magnetic Resonance Imaging, Hippocampal volume, MEDITERRANEAN DIET, ALZHEIMERS-DISEASE, Näringslära, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, HEALTHY EATING INDEX, 3121 General medicine, internal medicine and other clinical medicine, Older adults, Female, Diet, Healthy, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | BACKGROUND: Diet quality is associated with brain aging outcomes. However, few studies have explored in humans the brain structures potentially affected by long-term diet quality. We examined whether cumulative average of the Alternative Healthy Eating Index 2010 (AHEI-2010) score during adult life (an 11-year exposure period) is associated with hippocampal volume. METHODS: Analyses were based on data from 459 participants of the Whitehall II imaging sub-study (mean age [standard deviation] (SD) = 59.6 [5.3] years in 2002-2004, 19.2% women). Multimodal magnetic resonance imaging examination was performed at the end of follow-up (2015-2016). Structural images were acquired using a high-resolution 3-dimensional T1-weighted sequence and processed with Functional Magnetic Resonance Imaging of the Brain Software Library (FSL) tools. An automated model-based segmentation and registration tool was applied to extract hippocampal volumes. RESULTS: Higher AHEI-2010 cumulative average score (reflecting long-term healthy diet quality) was associated with a larger total hippocampal volume. For each 1 SD (SD = 8.7 points) increment in AHEI-2010 score, an increase of 92.5 mm(3) (standard error = 42.0 mm(3)) in total hippocampal volume was observed. This association was independent of sociodemographic factors, smoking habits, physical activity, cardiometabolic health factors, cognitive impairment, and depressive symptoms, and was more pronounced in the left hippocampus than in the right hippocampus. Of the AHEI-2010 components, no or light alcohol consumption was independently associated with larger hippocampal volume. CONCLUSIONS: Higher long-term AHEI-2010 scores were associated with larger hippocampal volume. Accounting for the importance of hippocampal structures in several neuropsychiatric diseases, our findings reaffirm the need to consider adherence to healthy dietary recommendation in multi-interventional programs to promote healthy brain aging. (C) 2018 The Authors. Published by Elsevier Inc. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0002-9343 1555-7162 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a71d3930e8f5b6b02606d79fc18ee846Test http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-362397Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....a71d3930e8f5b6b02606d79fc18ee846 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00029343 15557162 |
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