Modulating Microglial Cells for Promoting Brain Recovery and Repair
| العنوان: | Modulating Microglial Cells for Promoting Brain Recovery and Repair |
|---|---|
| المؤلفون: | Dirk M. Hermann, Matthias Gunzer |
| المصدر: | Frontiers in Cellular Neuroscience Frontiers in Cellular Neuroscience, Vol 14 (2021) |
| بيانات النشر: | DuEPublico, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Medizinische Fakultät » Universitätsklinikum Essen » Klinik für Neurologie, neuroplasticity, neurodegeneration, Medizin, blood-derived immune cell, neuroimmunology, brain injury, Medizinische Fakultät » Universitätsklinikum Essen » Institut für Experimentelle Immunologie und Bildgebung, brain ischemia, lcsh:RC321-571, Cellular Neuroscience, Perspective, ddc:610, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, neurorepair |
| الوصف: | Representing the brain’s innate immune cells that interact vividly with blood-derived immune cells and brain parenchymal cells, microglia set the stage for successful brain remodeling and repair in the aftermath of brain damage. With the development of pharmacological colony-stimulating factor-1 receptor inhibitors, which allow inhibiting or depleting microglial cells, and of transgenic mice, allowing the inducible depletion of microglial cells, experimental tools have become available for studying roles of microglia in neurodegenerative and neurorestorative processes. These models open fundamental insights into roles of microglia in controlling synaptic plasticity in the healthy and the injured brain. Acting as a switch from injury to repair, microglial cells might open opportunities for promoting neurological recovery in human patients upon brain injury. OA Förderung 2021 |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4c92aabcc9b2c98c5f91209bc1bbd2acTest https://duepublico2.uni-due.de/receive/duepublico_mods_00074018Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....4c92aabcc9b2c98c5f91209bc1bbd2ac |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |