Risk factors for herpes simplex virus type-1 infection and reactivation: Cross-sectional studies among EPIC-Norfolk participants
| العنوان: | Risk factors for herpes simplex virus type-1 infection and reactivation: Cross-sectional studies among EPIC-Norfolk participants |
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| المؤلفون: | Forbes, Harriet, Warne, Ben, Doelken, Lars, Brenner, Nicole, Waterboer, Tim, Luben, Robert, Wareham, Nicholas J., Warren-Gash, Charlotte, Gkrania-Klotsas, Effrossyni |
| المساهمون: | Forbes, Harriet [0000-0001-6888-2212], Warne, Ben [0000-0003-1326-0373], Apollo - University of Cambridge Repository |
| المصدر: | PLoS ONE PLoS ONE, Vol 14, Iss 5, p e0215553 (2019) |
| بيانات النشر: | Public Library of Science, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, Herpesviruses, Epidemiology, Science, viruses, Herpesvirus 1, Human, Pathology and Laboratory Medicine, Antibodies, Viral, Microbiology, Ethnic Epidemiology, Medicine and Health Sciences, Humans, Public and Occupational Health, Prospective Studies, Microbial Pathogens, Aged, Aged, 80 and over, Mouth, Biology and life sciences, Cancer Risk Factors, Organisms, Kidneys, Herpes Simplex, Renal System, Middle Aged, Socioeconomic Aspects of Health, United Kingdom, Herpes Simplex Virus, Health Care, Serology, Cross-Sectional Studies, Logistic Models, Oncology, Medical Microbiology, Viral Pathogens, Medical Risk Factors, Immunoglobulin G, Viruses, Herpes Simplex Virus-1, Medicine, Female, Virus Activation, Pathogens, Anatomy, DNA viruses, Research Article |
| الوصف: | BackgroundThe prevalence of, and risk factors for, herpes simplex virus type-1 (HSV-1) infection and reactivation in older individuals are poorly understood.MethodsThis is a prospective population-based study among community-dwelling individuals aged 40-79 years, followed from 1993, formed as a random subsample of the UK-based EPIC-Norfolk cohort. HSV-1 seropositivity was derived from immunoglobulin G measurements and frequent oro-labial HSV reactivation was self-reported. We carried out two cross-sectional studies using logistic regression to investigate childhood social and environmental conditions as risk factors for HSV-1 seropositivity and comorbidities as risk factors for apparent HSV oro-labial reactivation.ResultsOf 9,929 participants, 6310 (63.6%) were HSV-1 IgG positive, and 870 (of 4,934 seropositive participants with reactivation data) experienced frequent oro-labial reactivation. Being born outside the UK/Ireland, contemporaneous urban living and having ≥4 siblings were risk factors for HSV-1 seropositivity. Ever diagnosed with kidney disease, but no other comorbidities, was associated with an increased risk of frequent HSV reactivation (adjOR 1.87, 95%CI: 1.02-3.40).DiscussionApparent HSV-1 seropositivity and clinical reactivation are common within an ageing UK population. HSV-1 seropositivity is socially patterned while risk factors for oro-labial HSV reactivation are less clear. Further large studies of risk factors are needed to inform HSV-1 control strategies. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::39db0f333784047bf701e5e4ed761753Test http://europepmc.org/articles/PMC6508674Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....39db0f333784047bf701e5e4ed761753 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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