Impact of Nanoparticles on Male Fertility: What Do We Really Know? A Systematic Review
| العنوان: | Impact of Nanoparticles on Male Fertility: What Do We Really Know? A Systematic Review |
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| المؤلفون: | Klein, Jean-Philippe, Mery, Lionel, Boudard, Delphine, Ravel, Célia, Cottier, Michèle, Bitounis, Dimitrios |
| المساهمون: | Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Santé Ingénierie Biologie Saint-Etienne (SAINBIOSE), Centre Ingénierie et Santé (CIS-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP) |
| المصدر: | International Journal of Molecular Sciences International Journal of Molecular Sciences, 2023, 24 (1), ⟨10.3390/ijms24010576⟩ |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | nanosized objects, blood-testis barrier, [SDV]Life Sciences [q-bio], reprotoxicity, testicular biodistribution |
| الوصف: | International audience; The real impact of nanoparticles on male fertility is evaluated after a careful analysis of the available literature. The first part reviews animal models to understand the testicular biodistribution and biopersistence of nanoparticles, while the second part evaluates their in vitro and in vivo biotoxicity. Our main findings suggest that nanoparticles are generally able to reach the testicle in small quantities where they persist for several months, regardless of the route of exposure. However, there is not enough evidence that they can cross the blood-testis barrier. Of note, the majority of nanoparticles have low direct toxicity to the testis, but there are indications that some might act as endocrine disruptors. Overall, the impact on spermatogenesis in adults is generally weak and reversible, but exceptions exist and merit increased attention. Finally, we comment on several methodological or analytical biases which have led some studies to exaggerate the reprotoxicity of nanoparticles. In the future, rigorous clinical studies in tandem with mechanistic studies are needed to elucidate the real risk posed by nanoparticles on male fertility. |
| تدمد: | 1422-0067 1661-6596 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2126cbe8eb209c88b880441c52965856Test https://pubmed.ncbi.nlm.nih.gov/36614018Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....2126cbe8eb209c88b880441c52965856 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 16616596 |
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