IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways
| العنوان: | IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways |
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| المؤلفون: | Hwang, Sue-Yun, Kim, Ju-Young, Kim, Kyoung-Woon, Park, Mi-Kyung, Moon, Youngmee, Kim, Wan-Uk, Kim, Ho-Youn |
| المصدر: | Arthritis Research & Therapy |
| بيانات النشر: | BioMed Central, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | rheumatoid arthritis, Interleukin-15, phosphatidylinositol 3-kinase, Receptors, Interleukin-17, Interleukin-6, Interleukin-17, Interleukin-8, Synovial Membrane, NF-kappa B, Transcription Factor RelA, Receptors, Interleukin, Fibroblasts, Middle Aged, Protein Serine-Threonine Kinases, Arthritis, Rheumatoid, IL-17, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins, Humans, Mitogen-Activated Protein Kinases, fibroblast-like synoviocytes, Proto-Oncogene Proteins c-akt, Cells, Cultured, Research Article, Signal Transduction |
| الوصف: | Recent studies of the pathogenesis of rheumatoid arthritis (RA) have revealed that both synovial fibroblasts and T cells participate in the perpetuation of joint inflammation as dynamic partners in a mutual activation feedback, via secretion of cytokines and chemokines that stimulate each other. In this study, we investigated the role of IL-17, a major Th1 cytokine produced by activated T cells, in the activation of RA synovial fibroblasts. Transcripts of IL-17R (IL-17 receptor) and IL-17RB (IL-17 receptor B) were present in fibroblast-like synoviocytes (FLS) of RA patients. IL-17R responded with increased expression upon in vitro stimulation with IL-17, while the level of IL-17RB did not change. IL-17 enhanced the production of IL-6 and IL-8 in FLS, as previously shown, but did not affect the synthesis of IL-15. IL-17 appears to be a stronger inducer of IL-6 and IL-8 than IL-15, and even exerted activation comparable to that of IL-1beta in RA FLS. IL-17-mediated induction of IL-6 and IL-8 was transduced via activation of phosphatidylinositol 3-kinase/Akt and NF-kappaB, while CD40 ligation and p38 MAPK (mitogen-activated protein kinase) are not likely to partake in the process. Together these results suggest that IL-17 is capable of more than accessory roles in the activation of RA FLS and provide grounds for targeting IL-17-associated pathways in therapeutic modulation of arthritis inflammation. |
| اللغة: | English |
| تدمد: | 1478-6362 1478-6354 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid________::cbf27a06121514c8ebfc811c08e9ab59Test http://europepmc.org/articles/PMC400429Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid..........cbf27a06121514c8ebfc811c08e9ab59 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14786362 14786354 |
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