Diabetic muscle infarction is a rare complication of diabetes mellitus that typically presents in the thigh; microvascular abnormalities may play a role.A 32-year-old female presented at the outpatient clinic with a painful, swollen thigh. She had suffered from type 1 diabetes for 22 years. The patient was admitted to the nephrology ward for further evaluation. Deep-venous thrombosis and abscess were excluded with echography. After additional investigations - MRI and a biopsy of skin, muscle and fascia - the diagnosis diabetic muscle infarction was made. The patient was treated with bed rest and analgesics. With hindsight, the muscle biopsy was not actually required in reaching a diagnosis.The diagnosis 'diabetic muscle infarction' is made on the basis of clinical presentation in combination with MRI findings. The treatment consists of bed rest and analgesics.