Lysosomal cholesterol accumulation
| العنوان: | Lysosomal cholesterol accumulation |
|---|---|
| المصدر: | Obesity Reviews. 15(5):424-433 |
| بيانات النشر: | Wiley, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | E-DEFICIENT MICE, obesity, OXIDIZED LDL, REDUCES ATHEROSCLEROSIS, CYCLODEXTRIN OVERCOMES, LOW-DENSITY-LIPOPROTEIN, Cholesterol, lysosomes, MACROPHAGE FOAM CELLS, STORAGE DISORDERS, inflammation, WHITE CARNEAU PIGEONS, HEPATIC LIPOTOXICITY, METABOLIC SYNDROME |
| الوصف: | Many studies show an association between the accumulation of cholesterol inside lysosomes and the progression towards inflammatory disease states that are closely related to obesity. While in the past, the knowledge regarding lysosomal cholesterol accumulation was limited to its association with plaque severity during atherosclerosis, recently, a growing body of evidence indicates a causal link between lysosomal cholesterol accumulation and inflammation. These findings make lysosomal cholesterol accumulation an important target for intervention in metabolic diseases that are characterized by the presence of an inflammatory response. In this review, we aim to show the importance of cholesterol trapping inside lysosomes to the development of inflammation by focusing upon cardiovascular disease and non-alcoholic steatohepatitis (NASH) in particular. We summarize current data supporting the hypothesis that lysosomal cholesterol accumulation plays a key role in the development of inflammation during atherosclerosis and NASH. In addition, potential mechanisms by which disturbed lysosomal function can trigger the inflammatory response, the challenges in improving cholesterol trafficking in macrophages and recent successful research directions will be discussed. |
| اللغة: | English |
| تدمد: | 1467-789X 1467-7881 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=dris___01423::6aee3d5eb068a1caa20241ffe382778cTest https://research.rug.nl/en/publications/3d568ce5-b18d-43d7-8523-7928d6f8b5c3Test |
| رقم الانضمام: | edsair.dris...01423..6aee3d5eb068a1caa20241ffe382778c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1467789X 14677881 |
|---|