Combination of factor Xa inhibition and antiplatelet therapy after stenting in patients with iliofemoral post-thrombotic venous obstruction
| العنوان: | Combination of factor Xa inhibition and antiplatelet therapy after stenting in patients with iliofemoral post-thrombotic venous obstruction |
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| المؤلفون: | Isabell Bernlochner, Tareq Ibrahim, Michael Dommasch, Ralf J. Dirschinger, Karl-Ludwig Laugwitz, Nicolas Langwieser, Christian Bradaric, Juliane Jaitner, Isabel Wustrow |
| المصدر: | Phlebology: The Journal of Venous Disease. 31:430-437 |
| بيانات النشر: | SAGE Publications, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Ticlopidine, Adolescent, Platelet aggregation, Pharmacological management, Iliac Vein, 030204 cardiovascular system & hematology, Postthrombotic Syndrome, 03 medical and health sciences, 0302 clinical medicine, Rivaroxaban, medicine, Humans, In patient, cardiovascular diseases, 030212 general & internal medicine, business.industry, Mean age, General Medicine, Femoral Vein, Middle Aged, Clopidogrel, Venous Obstruction, Surgery, Anesthesia, Female, Stents, Once daily, Cardiology and Cardiovascular Medicine, business, Platelet Aggregation Inhibitors, Factor Xa Inhibitors, Follow-Up Studies, medicine.drug |
| الوصف: | Objectives Studies addressing optimal postprocedural pharmacological management after endovascular stenting of iliofemoral post-thrombotic venous obstruction are lacking. We report our early clinical experience with a combination of rivaroxaban and clopidogrel in patients after iliofemoral post-thrombotic venous obstruction stenting. Methods Demographic, procedural, and follow-up data of nine patients (seven women; mean age of 32 ± 11 years) undergoing 10 procedures for iliofemoral post-thrombotic venous obstruction performed between August 2012 and January 2014 were retrospectively reviewed. After endovascular intervention, all patients were administered 20 mg rivaroxaban once daily (s.i.d.) and 75 mg clopidogrel s.i.d. or every second day depending on the individual drug responsiveness for at least six months. The adenosine diphosphate-induced platelet aggregation (platelet aggregation, in aggregation units × min) was assessed on a Multiplate analyzer. Patency was verified venographically at procedure end and was evaluated with duplex ultrasound in regular follow-ups. Results Iliofemoral venous flow was successfully re-established by percutaneous endovascular angioplasty and stent implantation in nine left-sided and one bilateral iliofemoral post-thrombotic venous obstruction. Under dual treatment strategy of rivaroxaban and clopidogrel with platelet aggregation control (median (range): 285 aggregation units × min (192; 402)), none of the patients experienced restenosis or stent thrombosis, respectively. After a median follow-up of 14 months (range: 6–26 months), the primary patency rate was 100% and no in-stent restenosis, stent occlusion or relevant minor or major bleeding occurred. Conclusion Combined factor Xa inhibition and tailored antiplatelet therapy after stenting of iliofemoral post-thrombotic venous obstruction were safe and performed favorably in terms of vessel patency. |
| تدمد: | 1758-1125 0268-3555 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fffa77096b5b043b0ee07b9255cf4688Test https://doi.org/10.1177/0268355515596289Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....fffa77096b5b043b0ee07b9255cf4688 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17581125 02683555 |
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