Evaluation of Cerebral Blood Flow Measured by 3D PCASL as Biomarker of Vascular Cognitive Impairment and Dementia (VCID) in a Cohort of Elderly Latinx Subjects at Risk of Small Vessel Disease
| العنوان: | Evaluation of Cerebral Blood Flow Measured by 3D PCASL as Biomarker of Vascular Cognitive Impairment and Dementia (VCID) in a Cohort of Elderly Latinx Subjects at Risk of Small Vessel Disease |
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| المؤلفون: | Kay Jann, Xingfeng Shao, Samantha J. Ma, Steven Y. Cen, Lina D’Orazio, Giuseppe Barisano, Lirong Yan, Marlena Casey, Jesse Lamas, Adam M. Staffaroni, Joel H. Kramer, John M. Ringman, Danny J. J. Wang |
| المصدر: | Frontiers in Neuroscience, Vol 15 (2021) Frontiers in Neuroscience |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, cerebral blood flow, Posterior cerebral artery, 030218 nuclear medicine & medical imaging, lcsh:RC321-571, White matter, 03 medical and health sciences, 0302 clinical medicine, medicine.artery, Internal medicine, medicine, Dementia, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Original Research, medicine.diagnostic_test, business.industry, cerebral small vessel disease, General Neuroscience, white matter hyperintensity, Montreal Cognitive Assessment, item response theory, Neuropsychological test, medicine.disease, arterial spin labeling, medicine.anatomical_structure, Cerebral blood flow, Cohort, vascular cognitive impairment and dementia, Cardiology, business, Neurocognitive, 030217 neurology & neurosurgery, Neuroscience, circulatory and respiratory physiology |
| الوصف: | Cerebral small vessel disease (cSVD) affects arterioles, capillaries, and venules and can lead to cognitive impairments and clinical symptomatology of vascular cognitive impairment and dementia (VCID). VCID symptoms are similar to Alzheimer’s disease (AD) but the neurophysiologic alterations are less well studied, resulting in no established biomarkers. The purpose of this study was to evaluate cerebral blood flow (CBF) measured by 3D pseudo-continuous arterial spin labeling (pCASL) as a potential biomarker of VCID in a cohort of elderly Latinx subjects at risk of cSVD. Forty-five elderly Latinx subjects (12 males, 69 ± 7 years) underwent repeated MRI scans ∼6 weeks apart. CBF was measured using 3D pCASL in the whole brain, white matter and 4 main vascular territories (leptomeningeal anterior, middle, and posterior cerebral artery (leptoACA, leptoMCA, leptoPCA), as well as MCA perforator). The test-retest repeatability of CBF was assessed by intra-class correlation coefficient (ICC) and within-subject coefficient of variation (wsCV). Absolute and relative CBF was correlated with gross cognitive measures and domain specific assessment of executive and memory function, vascular risks, and Fazekas scores and volumes of white matter hyperintensity (WMH). Neurocognitive evaluations were performed using Montreal Cognitive Assessment (MoCA) and neuropsychological test battery in the Uniform Data Set v3 (UDS3). Good to excellent test-retest repeatability was achieved (ICC = 0.77–0.85, wsCV 3–9%) for CBF measurements in the whole brain, white matter, and 4 vascular territories. Relative CBF normalized by global mean CBF in the leptoMCA territory was positively correlated with the executive function composite score, while relative CBF in the leptoMCA and MCA perforator territory was positively correlated with MoCA scores, controlling for age, gender, years of education, and testing language. Relative CBF in WM was negatively correlated with WMH volume and MoCA scores, while relative leptoMCA CBF was positively correlated with WMH volume. Reliable 3D pCASL CBF measurements were achieved in the cohort of elderly Latinx subjects. Relative CBF in the leptomeningeal and perforator MCA territories were the most likely candidate biomarker of VCID. These findings need to be replicated in larger cohorts with greater variability of stages of cSVD. |
| تدمد: | 1662-4548 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa833b007751d7ebb4102c2a322da62Test https://pubmed.ncbi.nlm.nih.gov/33584191Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ffa833b007751d7ebb4102c2a322da62 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16624548 |
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