Molecular hybridization combining tumor homing and penetrating peptide domains for cellular targeting
| العنوان: | Molecular hybridization combining tumor homing and penetrating peptide domains for cellular targeting |
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| المؤلفون: | Vibin Ramakrishnan, Ruchika Goyal, Aneesh Chandrasekharan, Gaurav Jerath, Yvonne Christian, T. R. Santhosh Kumar |
| المصدر: | Drug Delivery and Translational Research. 12:1285-1292 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Chemistry, media_common.quotation_subject, Pharmaceutical Science, Antineoplastic Agents, Peptide, Cell-Penetrating Peptides, In vitro, Molecular hybridization, Cell biology, Drug Delivery Systems, Protein Domains, Cell Line, Tumor, Drug delivery, Cell-penetrating peptide, Tumor homing, Internalization, Cytotoxicity, media_common |
| الوصف: | A complete peptide-based drug delivery unit has been designed with a tumor homing domain chemically linked to a syndiotactic cell-penetrating domain. The designed peptides were synthesized, characterized, and tested in vitro for cellular uptake and cytotoxicity evaluation. The differential uptake, cellular internalization, negligible hemotoxicity, selective toxicity to MDA-MB-231 breast cancer cells, and the superior penetration in three-dimensional MDA-MB-231 tumorospheres confirm their utility as a promising delivery vector. |
| تدمد: | 2190-3948 2190-393X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff60139ce88498150f5c09a98353e504Test https://doi.org/10.1007/s13346-021-01035-zTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....ff60139ce88498150f5c09a98353e504 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21903948 2190393X |
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